lecture 10 and 11 Flashcards
(23 cards)
reserpine
irreversibly impairs ATPases in granules filled with NA. can be used as indicator for essential hypertension
clonidine
alpha 2 receptor agonist, inhibiting NA release
a-methyldopa
antisympathetic drug, used for treatment when dopamine is not produced because the wrong neurotransmitter is produced
tocolysis
contractions during pregnancy, treated with beta2 mimetic drug
muscle tremor
side effect of beta2 stimulation
alpha sympathomimetic drugs
gets rid of mucus while being used, activation of central alpha2 receptors and anti-sympathetic effect
non specific alpha blocker
blocks target receptor (A1) but also A2 which causes unwanted side effect
specific alpha blocker
reversible, prazosin, very good for hypertension treatment
ISA
intrinsic sympathomimetic activity, partial agonist or partial antagonist
pindolol
frequently used partial agonist
isoprenaline
beta 1 agonist
non-specific beta blocker
indications can be severe thyroid overactivity, timolol is indicator
receptor desensitization
reduction of receptor-dependent effects with long term use
down regulation
reduction in number of functioning receptors
tachyphylaxis
the body becomes unresponsive to the pharmacon within a short period of time
tolerance
gradual reduction in the bodys sensitivity to repeated and/or long term use of the pharmacon
P2X receptor
ligand gated ion channels, ATP
P2Y receptor
GPCR, ADP
A(P1) receptor
GPCR, adenosine
P1 receptors
subtypes A1, A2, A3. GPCR
P2 receptors
subtypes P2X and P2Y
caffeine and theophylline
antagonist, blocks adenosine and phosphodiesterases causing increase in cAMP
suramin
antagonist working on P2Y receptors, ADP
