lecture 8

Question 1

MAO

Answer 1

metabolizes serotonin to eventually form 5HIAA

Question 2

SERT

Answer 2

widespread and limits the action of 5-HT

Question 3

SSRI

Answer 3

exaggerate the 5-HT action

Question 4

5HT1 receptors

Answer 4

expressed in the brain, inhibitory presynaptically, and adenylyl cyclase

Question 5

triptan

Answer 5

5HT1 receptor agonist, treating migraines

Question 6

buspirone

Answer 6

5HT1 receptor agonist, treating anxiety

Question 7

spiperone

Answer 7

5HT1 receptor antagonist

Question 8

5HT1A

Answer 8

regulate mood and behaviour

Question 9

5HT1B and D

Answer 9

expressed in cerebral large vessels and are targets for drugs against migraines

Question 10

5HT2 receptors

Answer 10

expressed in CNS and periphery

Question 11

LSD

Answer 11

5HT2 agonist in CNS, potent hallucinogen. in periphery antagonist

Question 12

5HT2A

Answer 12

clonic motility

Question 13

5HT2B

Answer 13

heart defects

Question 14

5HT2C

Answer 14

CNS disorders

Question 15

5HT3 receptors

Answer 15

expressed in periphery and in CNS, cause excitation via ion channels

Question 16

2-methyl-5HT

Answer 16

5HT3 agonist

Question 17

ondansetron

Answer 17

5HT3 and 4 antagonist

Question 18

5HT4 receptor

Answer 18

expressed in CNS and periphery, excitatory via AC but mainly GI

Question 19

metoclopramide

Answer 19

dopamine antagonist, antiemetic activity, 5HT4 antagonist