lecture 5 Flashcards
(12 cards)
receptors of the heart
B1 adrenoreceptor and M2 cholinergic receptor
receptors of the arterioles
a1, a2, constriction large coronary. B2 dilation small coronary
receptors of the bronchi
B2 receptor for circulating adrenaline. constriction and secretion via M3.
receptors of the skin
cholinergic secretion via M3 receptor
presynaptic modulation
sympathetic and parasympathetic affect each other by directly releasing each others neurotransmitter onto each other.
neuromodulation
generally involve second messenger regulation of membrane ion channels
autoinhibitory feedback
transmitter inhibits its own release
prazosin
alpha1 antagonist
presynaptic inhibition
part of the neurotransmitter gives negative feedback and doesnt reach the target receptor. In many NA and cholinergic terminals
heterotropic presynaptic inhibition
axons give negative feedback to each other and have opposing effects. in NA/cholinergic nerve terminals in the heart
postsynaptic synergism
one neurotransmitter enhances the effect of the other or two neurotransmitters stimulate the same effect via different ways
exocytosis
release of content from the axon into the synaptic cleft