Lecture 10 - Prions Flashcards Preview

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Flashcards in Lecture 10 - Prions Deck (18):
1

What are TSEs?

Transmissible Spongiform Encephalopathies (TSEs)

2

What type of disease is TSE?

Neurodegenerative disease leading to death

3

Prions lack what?

A genome

4

How can TSE be diagnosed?

Only by autopsy

5

Scrapie is apparent in what species?

Sheep and goats, not in humans!

6

Prions are...

Protein + Infection located on the surface of neurons

7

PrPc

Cellular prion protein that is highly conserved in animals and is non-infectious

8

PrPSc

Infected form of cellular prior protein for scrapie.

9

PrPSc lacks what...

Nucleic acids, but is still infectous

10

PrPSc is derived from?

PrPc

11

3 Differences between PrPc and PrPSc

PrPc - alpha helices, soluble, not sticky.
PrPSc - beta-sheets, insoluble, sticky

12

How is PrPSc synthesized?

PrPc is made in the nucleus and brought to the cell surface. PrPSc from another cell comes and alters PrPc to form PrPSc. PrPSc is taken in by endocytosis and is accumulated in cell causing cell death

13

How does the cell break down PrPc

By proteases, Sc is resistant to these!!

14

Where is PrPc most commonly found in the body?

Brain

15

Better name for Bovine Spongiform enecephalopathy

MAD COW

16

How is mad cow disease occurring

Cows being fed other cows remains, and the humans eating those infected cows

17

Three types of CJD (Creutzfeldt-Jakob Disease)

sporadic, hereditary and latrogenic

18

Kuru (symptoms, transmission)

Body tremors and obtained from cannabilism