Flashcards in Lecture 10 - Prions Deck (18):
What are TSEs?
Transmissible Spongiform Encephalopathies (TSEs)
What type of disease is TSE?
Neurodegenerative disease leading to death
Prions lack what?
How can TSE be diagnosed?
Only by autopsy
Scrapie is apparent in what species?
Sheep and goats, not in humans!
Protein + Infection located on the surface of neurons
Cellular prion protein that is highly conserved in animals and is non-infectious
Infected form of cellular prior protein for scrapie.
PrPSc lacks what...
Nucleic acids, but is still infectous
PrPSc is derived from?
3 Differences between PrPc and PrPSc
PrPc - alpha helices, soluble, not sticky.
PrPSc - beta-sheets, insoluble, sticky
How is PrPSc synthesized?
PrPc is made in the nucleus and brought to the cell surface. PrPSc from another cell comes and alters PrPc to form PrPSc. PrPSc is taken in by endocytosis and is accumulated in cell causing cell death
How does the cell break down PrPc
By proteases, Sc is resistant to these!!
Where is PrPc most commonly found in the body?
Better name for Bovine Spongiform enecephalopathy
How is mad cow disease occurring
Cows being fed other cows remains, and the humans eating those infected cows
Three types of CJD (Creutzfeldt-Jakob Disease)
sporadic, hereditary and latrogenic