Lecture 5 - Meningitis Flashcards Preview

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Flashcards in Lecture 5 - Meningitis Deck (19):
1

Where are the meninges found?

Surrounding the CNS (SPINE + BRAIN)

2

What are the components of the meninge

pia mater (pink, sensitive), arachnoid mater (spongey), and the dura mater (skull)

3

Where is the spinal fluid located?

Between the pia mater and arachnoid mater

4

What is meningitis

Infection of the meninge from a virus or a bacteria

5

List the 10 steps of bacterial meningitis

1.) enters the body
2.) pushed into blood
3.) multiplies in blood
4.) crosses BBB
5.) invades into meninge
6.) proinflamation cytokines released
7.) recruit of leukocytes
8.) edema and increased cranial pressure
9.) inflammation
10.) neuron damage

6

What bacteria causes meningitis?

Almost all can do this!

7

Three methods to get across the BBB

Transcellular Transversal - right through
Paracellular Transversal - through tight junctions
Trojan-Horse Mechanism - intracellular pathogen invades immune cell and then moves across

8

2 methods of diagnosis

Blood testing that indicates inflammation and a spinal tap that produces a cloudy solution

9

Neisseria meningitis

G-, diplococcus

10

What species and where in that species is Neisseria meningitis found?

In humans nose/throat

11

In North America, what is the most common type of meningitis?

Type B

12

In Africa, what is the most common type of meningitis?

Type A

13

3 Vaccines for meningitis

Menactro/Menveo - 4 serotypes and Bexero - expensive/controversial

14

Streptococcus pneumoniae

G+ cocci

15

Strep penum vaccine

Prevnar 13 (Pfizer)

16

Haemophilus influenzae type b

HIB, G- coccobacillus

17

What type of pathogen is Listeria Monocytogenes

Food borne pathogen

18

Streptococcus agalactiae

G+ cocci, chain grower

19

Streptococcus agalactiae is what type of strep?

Group B -> GBS