Lecture 2 - Plague Flashcards Preview

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Flashcards in Lecture 2 - Plague Deck (20):
1

Yersinia

G-, rod shaped

2

3 Human Forms of Yersinia

enterocolitica, pseudotuberculosis, pestis

3

How does one die from Pestis

sepsis, pneumonia or resp failure

4

What type of Y. was Justinian pandemic?

Pestis

5

What type of Y. was the black plague pandemic

Pestis

6

How was the black plague spread globally?

Rats infected with lice moving on ships

7

Name for fleas/rats/human transmission?

Zoonotic pathogen

8

How did pestis effect fleas?

Began to starve them. The fleas would take blood meals from the infected rat, would cause bio film formation which caused starvation. This in turn caused them to get blood meals from humans causing more spread

9

Is Y. Pestis lethal?

Yes, takes only a tiny amount to be deadly

10

What immediately happens when Y. Pestis enters the human

Moves to lymph, causes swelling which forms buboes

11

Pestis virulence factors

Type 3 secretion, phospholipase, LPS, plasminogen activator

12

Where do we see the VF "type III secretions"

Only in G-

13

3 types of plague

Bubonic, Septicemic, pneumonic

14

Worst type of plague

Pneunmonic

15

Bubonic plague characteristics

Most common, by fleas, swollen lymph nodes, can develop into the other two forms

16

Septicemic plague characterisitcs

Present in blood, black fingers

17

Pneumonic plague characteristics

Transmitted via aerosols and very short incubation time. Certain death

18

How was plague tranmitted

Fleas, handling infected animals or eating infected animal meat

19

How is plague diagnosed?

Using stain and antigen testing

20

How are outbreaks of plague now handled?

Using insecticides to kill the fleas