Lecture 2 Flashcards
(30 cards)
What does haematopoiesis mean
Formation of blood cellular component
Where do B cells develop in mammals
Bone marrow
Where do B cells develop in birds
Bursa
Which cells are phagocytic cells (2)
Monocytes
Neutrophils
Name the 3 granulocytes
- Neutrophils - neural granules
- Eosinophils - granules stain red
- Basophils - stain with basic dyes
Where there is a high count of Eosinophils what could it be infected with
Parasites
Which granulocyte is important in allergic reactions
Basophils
How long do neutrophils spend in the blood stream
12 hours
Function of the neutrophils
capture and destruction of foreign material
What is the half life of an Eosinophil
30 minutes
What is the function of basophil
May be involved in hypersensitivity and allergy
Where are macrophages located
Tissue
Name the 5 cytokines secreted by macrophages
- Interluekin-1
- Interleukin-6
- Interleukin-12
- Interleukin-18
- Tumor necrosis factor-a
What are dendritic cells
Getting an immune response
What are dendritic cells derived from
Myeloid progenitors
What is the function of dendritic cells
They take up antigen, process it and display the antigen for recognition by T cells
What cells build the bridge between innate and adaptive immunity
Dendritic cells
What are the primary lymphoid organs (3)
- Bone marrow
- Thymus
- Bursa of Fabricius
What are the secondary lymphoid organs (3)
- Spleen
- Lymph nodes
- MALT
What do primary lymphoid follicles become when there is Ag present
Germinal centres
Where does isotope switching occur
Germinal centres
Where are T cells located in the lymph node
Paracortex
Where are B cells located in the lymph node
Follicles
Where are Dendritic located in the lymph node
Paracortex
