Lecture 6 Flashcards
(35 cards)
What are the compartments of the immune system (4)
- Peripheral lymph nodes and spleen
- Skin
- MALT
- Body cavity
What is the mucosa surface
Interface between external and internal environment
What is the mucosal surface vulnerable to
Infection
What is MALT
Distinct accumulation of lymphoid tissue in the GIT system
What is the dominant immunoglobin in MALT
Immunoglobin A (Ig A)
What is common mucosal immune system
Priming of lymphocytes in one mucosal tissue can induce protective immunity at other mucosal surfaces
What is circulation of lymphocytes within the mucosal immune system is controlled by
Tissue-specific adhesion molecules and chemokine receptors
How do microbial antigens enter the body
for gut lumen via different ways and reach antigen presenting cells below epithelium
What can be found in the intestinal wall
M cells and dendritic cells
What happens to the antigens that enters enterocytes
Usually degraded
How to lymphocytes stimulated in the Peyer’s patches leave the intestine
in blood
Where do lymphocytes stimulated in the Peyer’s patches settle
Back in the intestine or other mucosal sites and produce Abs and cytokines
What do innate mechanisms involve
Protection of the respiratory tract against infection
What does the mucous contain
Host defence molecules, enzymes, Abs, surfactant
What in the main Ig of immunity in the respiratory tract
IgA
What are the main immune cels found in airways
Macrophages
What can bind to Ag
IgA, IgE and IgG
What sort of immunity do new born animals have
Passive immunity
What Ig does milk supple
IgA
What is colostrum rich in
IgG, IgA, IgE and IgM
Absorption of what provides systemic immunity
IgG
Why is the prolonged intake of milk necessary
To ensure protection of GIT against enteric infection
What does maternal Abs inhibit the newborn to do
Mount its own immune responses
When is the best time to vaccinate a newborn
When maternal Ab is declining
