Lecture 39 Flashcards Preview

Medical Biochem and Genetics > Lecture 39 > Flashcards

Flashcards in Lecture 39 Deck (7)
Loading flashcards...
1
Q

Triacylglycerol Lipase is activated by ______ via PKA.

A

activated by PHOSPHORYLATION

2
Q

The _____ shuttle is the major way Long chain fatty acids are oxidized. This beta-oxidation occurs within the _____ of the cells.

A

CARNITINE shuttle. Beta-oxidation of long chain fatty acids occurs in the MITOCHONDRIAL MATRIX

3
Q

____ catalyzes the rate limiting step in fatty acid oxidation which binds Carnitine to fatty acyl CoA. It is inhibited by _____ CoA.

A

CPT1. It is inhibited by MALONYL CoA.

4
Q

CPT2 removes _____ from fatty acyl CoA once it passes the inner mitochondrial membrane.

A

Removes CARNITNE

5
Q

Oxidation of fatty acyl CoA in the mito produces 3 important products: _____ (used at complex II in ETC), _____ (used at complex I in ETC), and ______ (that enters into TCA.)

A

FADH2, NADH, and Acetyl CoA

6
Q

MCADD is an _____ recessive mutation in the enzyme involved in the first step of _____ chain fatty acid oxidation.

A

AUTOSOMAL recessive mutation in the enzyme involved in the first step of MEDIUM chain fatty acid oxidation.

7
Q

D-beta-hydroxybutarate can be converted back to acetoacetate to eventually reform 2 molecules of ______.

A

Eventually form 2 molecules of ACETYL CoA