Lecture 43 Flashcards Preview

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Flashcards in Lecture 43 Deck (5)
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1
Q

There are two isoforms of COX (1 and 2.) COX 1 is ______ active, whereas COX 2 is ______ (usually by trauma or inflammatory response) and is present in immuno-competent cells.

A

COX 1 is CONSTITUTIVE, whereas COX 2 is INDUCIBLE and is present in immuno-competent cells.

2
Q

COX enzymes have 2 activities: _______ and ______ to form PGH2.

A

CYCLIZATION and PEROXIDATION

3
Q

____ is the protaglandin involved with development, regulation, and activity of many immune cells.

A

PGE2

4
Q

_____ had the opposite effect of Thromboxanes in areas where blood clots should not be forming.

A

PGI2

5
Q

Aspirin works by blocking both COX enzymes. The ____ group of Aspirin binds to ____ on the COX enzymes.

A

ACETYL group of aspirin bind SERINE on COX