Flashcards in Lecture 43 Deck (5)
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1
Q
There are two isoforms of COX (1 and 2.) COX 1 is ______ active, whereas COX 2 is ______ (usually by trauma or inflammatory response) and is present in immuno-competent cells.
A
COX 1 is CONSTITUTIVE, whereas COX 2 is INDUCIBLE and is present in immuno-competent cells.
2
Q
COX enzymes have 2 activities: _______ and ______ to form PGH2.
A
CYCLIZATION and PEROXIDATION
3
Q
____ is the protaglandin involved with development, regulation, and activity of many immune cells.
A
PGE2
4
Q
_____ had the opposite effect of Thromboxanes in areas where blood clots should not be forming.
A
PGI2
5
Q
Aspirin works by blocking both COX enzymes. The ____ group of Aspirin binds to ____ on the COX enzymes.
A
ACETYL group of aspirin bind SERINE on COX