Lecture 42 Flashcards Preview

Medical Biochem and Genetics > Lecture 42 > Flashcards

Flashcards in Lecture 42 Deck (8)
Loading flashcards...
1
Q

In adipocytes, Glycerol-3-P can be formed by reducing _____ using NADH, whereas in the liver it can be formed by direct phosphorylation of Glycerol via the enzyme ________.

A

In adipocytes, DHAP is reduced to for Glycerol-3-P, whereas in the liver it can be formed via the enzyme GLYCEROL KINASE

2
Q

Phospholipase ____ acts on phosphatidylinositol to form arachidonic acid. It is inhibited by ______ (i.e. Cortisol.)

A

Phospholipase A2 acts on phosphatidylinositol to form arachidonic acid. It is inhibited by GLUCOCORTICOIDS.

3
Q

Phospholipase ____ is found in the liver, and its action activates the PIP2 system

A

Phospholipase C is found in the liver

4
Q

_____ serve as precursors to Sphingomyelin and Glycosphingolipids

A

CERAMIDES

5
Q

_____ CoA is the precursor for Sphingolipids in general. Sphingosine is synthesized from _____CoA and the AA _____.

A

PALMITOYL CoA. Sphingosine is synthesiszed from PALMITOYL CoA and SERINE.

6
Q

Tay Sachs disease results from a deficiency in the enzyme Beta-_________. It is characterized by accumulation of _______ and has symptoms such as cherry-red _____, muscular weakness, and blindness.

A

Deficiency in Beta-HEXOSAMINIDASE A. It is characterized by accumulation of GANGLIOSIDES and has symptoms such as cherry-red MACULA…

7
Q

Gaucher disease results from a deficiency in Beta-______. It is characterized by accumulation of gluco_______ and has symptoms such as hepato_______ and osteoporosis of long bones.

A

Results from deficiency in Beta-GLUCOSIDASE. Accumulation of glucocerebrosides and has symptoms such as hepatoSPLENOMEGALY and osteoporosis of long bones.

8
Q

Nieman-Pick disease results from a deficiency in _______. This results in accumulation of ______, leading to symptoms such as cherry-red _____, neurodegeneration, and hepato______.

A

Deficiency in SPHINGOMYELINASE resulting in accumulation of SPHINGOMYELIN, leading to symptoms such as cherry-red MACULA, neurodegeneration, and hepatoSPLENOMEGALY.