Lecture 4 Tissue repair and injury Flashcards Preview

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Flashcards in Lecture 4 Tissue repair and injury Deck (21):
1

Define regeneration

Complete reconstitution

2

What is needed for regeneration?

Tissue with high proliferation, viable stem cells and intact connective tissue (scaffolding)

3

Define repair

Combination of regeneration and scar formaiton

4

What does repair rely on?

Capacity to regenerate, extent of injury and extent of scaring.

5

Examples of regeneration

Liver regeneration after partial hepatectomy, superficial skin wounds, resorption of exudate in lobar pneumonia.

6

Examples of repair

Deep excisional wounds, myocarium infaction

7

Examples of fibrosis

Chronic inflam diseases, cirrhosis, pancreatitis, pulmonary fibrosis.

8

2 limited examples of true regeneration?

epithelium following superficial skin injury & bone after fracture.

9

Example of hypertrophy to compensate

Nephrons following nephrectomy

10

Example of hyperplasia to compensate

Hepatocytes following partial hepatectomy

11

Fibro-proliferative response is when

Deposition of collagen and ECM component (scar). "patches" tissue.

12

Sequence of healing 5 steps?

Inflam, angiogenesis, migration & prolife of parenchymal cells &fibroblasts, scar, connective tissueremodelling.

13

When healing a larger scab what happens to the inflammation?

More nacrotic debris, exudate and fibrin to remove -> inflam more intense

14

Define granulation tissue

New connective tissue with tiny blood vessels

15

What does a larger amount of granulation tissue mean?

a larger defect. Involves wound contraction

16

What local factors affect wound healing?

Size, location (how well its vascularised), type (infectious/necrotic/traumatic), infections.

17

What systemic factors affect would healing?

Nutritional status, metabolic status (diabetes), circulatory/vascular status, hormones (glucocorticoids).

18

What can complicate repair?

Deficient scar formation -> wound dehiscence (wound ruptures along surgical line)

19

Excessive repair complications (3)

Excessive granulation tissue (proud flesh), excessive collagen accumulation (hypertrophic scar), Keloid.

20

Define keloid

area of irregular fibrous tissue formed at the site of a scar or injury

21

Repair complication - formation of contractures

Contracture of skin due to burn.