Lecture 4.5 Lipid drugs (from Pharm exam) Flashcards Preview

ICM - Endocrine > Lecture 4.5 Lipid drugs (from Pharm exam) > Flashcards

Flashcards in Lecture 4.5 Lipid drugs (from Pharm exam) Deck (21):
1

what drug class causes the largest drop in TG's? what about LDL? What drug class increases HDL the most?

fibrates; statins; niacin

2

statins (competitively or non-competitively) inhibit ______. they also upregulate _____

competitively inhibit HMG CoA reductase;LDL receptors = reduces plasma chol

3

statins are indicated in patients with high _____ or those that have had an _____

LDL, acute MI
reduce LDL by 20-60%

4

short half-life statins should be taken in the _____.

evening (to inhibit nocturnal synthesis)

5

what is the most common side effect of statins? how do you follow this?what is another important side effect?

rhadomyolysis/myopathy, follow with CPK;
hepatotoxicity (Follow LFTs)

6

mechanism of action of bile acid resins:

prevent intestinal reabsorption of bile acids by forming insoluble complexes with them;upregulate LDL receptors

7

name 3 bile acid resins

cholestyamine, colestipol, colesevelam

8

bile acid resins primary effect on lipoproteins:

decrease LDL (by 20%); slightly increase HDL

9

side effects of bile acid resins (2)

GI upset, decreased absorption fat soluble vitamins/drugs ie statins

10

what drug inhibits small intestinal absorption of cholesterol?

ezetimibe

11

ezetimibe primarily reduces ____;

LDL;
rarely causes liver/muscle damage

12

alirocumab and evolocumab both inhibit ____.

PCSK9 protein

13

what does PCSK9 usually do?

promotes degradation of LDL receptors

14

fibrates activate ____ to upregulate ____ and induce ____ synthesis

PPAR alpha; Lipoprotein lipase, HDL

15

hit me with 2 fibrates:

fenofibrate, gemfibrozil
others exist as well

16

fibrates are especially indicated in patients with ____ in which VLDLs predominate

hyper-TG-emia

17

2 side effects of fibrates

myopathy (watch with statins);gall stones

18

what dietary supplement can reduce TG synthesis?

omega 3 FA (Fish oil/lovaza)

19

niacin is thought to increase ____ activity and decrease _____ production. niacin ____ hormone synthesis lipase in adipose tissue

lipase (increases VLDL clearance);
VLDL (in liver);
inhibits

20

most common side effect of niacin:
how to help treat this?

cutaneous vasodilation, warmth;
use NSAIDs (inhibits PG release)

21

3 other side effects of niacin:

hyperglycemia, hyperuricemia, hepatotoxicity