Lecture 2 - Hyperthyroid Flashcards Preview

ICM - Endocrine > Lecture 2 - Hyperthyroid > Flashcards

Flashcards in Lecture 2 - Hyperthyroid Deck (23):
1

most thyroid hormone in the blood is (unbound/bound) and (active/inactive)

bound (99.9%), inactive

2

OCPs, estrogens, and pregnancy all increase ___ T4, and have normal ___ T4 by ______ TBG.

total;
free;
increasing

3

Glucocorticoids, cirrhosis, and nephrotic syndrome are examples where there is ____ TBG, ____ total T4, and ____ free T4

decreased, decreased, normal

4

hyperthyroidism:
tachycardia, arrythmias due to increased ____;
weight loss, increased appetite, and sweating due to increased _____, which increases the _____

B1 receptors;
Na-K+ pumps, BMR

5

hyperthyroidism:
____ hair;
_____ myxedema in graves disease;
stare and lid lag due to _____

fine;
pretibial;
increased symp firing

6

name 2 common medications that affect thyroid function

amiodarone, lithium

7

grave's disease and toxic multinodular goiter show ____ uptake of radioiodine. subacute thyroiditis and hashimotos show ____ uptake of radioiodine

increased;
decreased

8

hyperthyroidism in the elderly:
usually present with ____ problems such as _____. ____ is often a prominent feature

cardiac, AFib;
myopathy

9

clinical triad in Grave's disease:

goiter, pretibial myxedema, exopthalmus

10

graves: proliferation of _____ and secretion of ______ leading to edema cause the symptoms of exopthalmus

fibroblasts, GAGs

11

grave's patients often have limited ability to look ____ due to ____ and _____ _____ rectus muscles

superiorly;
thickened, shortened inferior

12

toxic multinodular goiter is characterized by ______ follicular cells that (do or do not) respond to TSH

autonomous/hyperactive
do not

ie "Hot nodule"

13

in addition to thiomides, what 2 drugs are used in management of graves disease?

both do what

beta blockers, corticosteroids;

decrease T4 to T3 conversion

14

in a pregnant woman with graves:
____ should be used in the first trimester to avoid the risk of ____ when ____ is used

PTU;
aplasia cutis, methimazole

15

PTU has a black box warning for ____

liver toxicity

16

radiation in hyperthyroidism:
can worsen pre-existing ____;
_____ in thyroid hormone levels 1-2 weeks after treatment, which can cause a ______

exopthalmus in graves;
increase;
thyroid storm (if v high levels)

17

thyroid storm:
usually occurs when hyperthyroidism is incompletely treated and worsens in the setting of ____ such as ____, trauma, or surgery

acute stress;
infection

18

thyroid storm:
very high ____;
diarrhea, coma;
cause of death is usually ____

fever;
tachyarrhythmia

19

the 4 P's of treating thyroid storm

propanolol (a beta blocker);
propylthiouracil;
Prednisolone (corticosteroids);
Potassium iodide (administer after PTU)

20

Dequarvains/Granulomatous thyroiditis:
painful or painless?
usually occurs following _____;
self limited or no?

PAINFUL AF;
infection (virus);
yes; give patient NSAIDs

21

thyroiditis (silent/lymphocytic):
initially ____, progresses to ____

hyperthyroidism, hypothyroid

22

thyroid surgery:
can damage ______ causing hoarsness,
can remove Parathyroid glands causing ____

recurrent laryngeal;
hypocalcemia

23

hyper vs hypothyroid:
osteoporosis =
hypercholesterolemia =
hyperglycemia =

hyper;
hypo;
hyper