Lecture 3 - Hypothyroid Flashcards Preview

ICM - Endocrine > Lecture 3 - Hypothyroid > Flashcards

Flashcards in Lecture 3 - Hypothyroid Deck (22):
1

wolf-chaikoff:

____ doses of iodine cause a ____ in hormone production

high;
decrease

2

jod-basedow effects:

____ doses of iodine causes a ____ in hormone production

high, increase;

seen in hyperthyroid patients

3

hypothyroidism:
_____myxedema, causing a large ____ and deepening of the _____;
____, ____ hair

facial/periorbital;
tongue, voice;
coarse, brittle

4

primary hypothyroidism:
____ free T4, _____ TSH;

secondary hypothyroidism:
____ free T4, ____ TSH

low, high;

low, normal or low

5

drug of choice for hypothyroidism:

side effects?

levothyroxine;

hyperthyroid symptoms ie tachycardia, arrythmias

6

hashimoto's:
HLA ____ associated;
anti ______ and anti _____ antibodies;
increased risk of ____ cancer

DR5;
thyroid peroxidase, thyroglobulin;
marginal zone

7

riedel thyroiditis:
seen in ____ women;
presence of _____;
goiter is described as ____ and _____

younger (vs anaplastic carcinoma);
fibrosis (extending to other structures);
painless, rock hard

8

pregnancy causes an increase in ____ synthesis due to ____ stimulation. T4 and T3 levels ____ in the first trimester

Thyroid-binding globulin;
estrogen;
increase

9

in patients with hypothyroidism, what is seen when the check DTRs?

delayed relaxation phase

and delayed DTRs

10

in pregnancy, ____ has intrinsic thyrotropic activity;

in the second and third trimesters, thyroid levels ____

HCG;
decrease

11

myxedema coma:
low _____ leads to build up of ____ within cell leading to cellular _____

metabolism;
metabolites;
edema

12

myxedema coma:
____ edema; _____ cardiac output and _____ perfusion, organ failure

non-pitting (widespread); decreased, decreased

13

thyroid cancer nodules are usually ____ on scan. thyroid cysts are (likely or unlikely) to be cancer

cold;
unlikely

14

thyroid cancer is typically diagnosed with _____

fine needle aspirate

15

iron and calcium _____ thyroid hormone absorption

decrease

also anti-acids, PPIs, bile acid resins

16

childhood irradiation is especially associated with _____ carcinoma

papillary

17

____ carcinoma is characterized by malignant cells on an amyloid stroma. ____ levels are increased

medullary;
calcitonin

18

psammoma bodies and orphan annie nuclei are seen in ____ carcinoma

papillary

19

____ carcinoma invateds the thyroid capsule and vasculature. spreads ______

follicular;
hematogenously

20

_____ carcinoma is seen in older patients and is highly invasive

anaplastic

21

first lab to use in hypothyroid patients

TSH

22

_____ thyroid cancer is associated with MEN II. due to mutation in ____ gene

medullary;
RET

need prophylactic thyroidectomy