Lecture 1 - Pituitary Flashcards Preview

ICM - Endocrine > Lecture 1 - Pituitary > Flashcards

Flashcards in Lecture 1 - Pituitary Deck (24):
1

the anterior pituitary is derived from _____. the posterior pituitary is derived from _____;
the pituitary gland is located in the _____

oral ectoderm (Rathke's pouch);
neuroectoderm;

sella turcica

2

TRH stimulates the release of what

TSH, prolactin

3

dopamine _____ prolactin secretion. prolactin inhibits ______

inhibits;
GnRH secretion

4

most common pituitary tumor>?

prolactinoma (diagnosed early);

GH tumor less common, diagnosed late

5

mass effects of pituitary adenomas:
_____ (visual), ____pituitarism, headache

bitemporal hemianopia, hypo

6

prolactin may be increased in response to _____ antagonists; they may also be increased in ___thyroidism

dopamine;
hypo (due to increased TRH)

7

presentation of prolactinoma:
in women: ____, ____, ____ bone density due to ____ in estrogen

galactorrhea, amenorrhea, decreased;
inhibition

8

prolactinoma in men:
_____ and _____

low libido, infertility

9

treatment of prolactinoma: _____ is first line. examples = ?

dopamine agonists;
cabergoline, bromocriptine, pergolide

10

GH is released in a ____ manner, usually at _____.

pulsatile, night

11

what mediator is measured to look at GH levels?
this mediator causes ____, _____ resistance, and ____ growth

IGF1;
lipolysis, insulin, muscle

12

GH excess:
____ in kids, ____ in adults; typically due to _____

gigantism, acromegaly;

pituitary adenoma (large )

13

acromegaly:
large ____ and ____, frontal _____, excessive ____, impaired ____ tolerance

hands, feet;
blossing;
sweating;
glucose (2ndary type 2 DM)

14

acromegaly diagnosis:

increased serum ____. failure to suppress serum ____ following oral _____

IGF1;
GH, glucose

15

acromegaly treatment:
____ is first line.
if not cured, treat with _____, a somatostatin analog or _____, a GH receptor antagonist

surgery;
octreotide, pegvisomant

16

acromegaly complications:
increased risk of ____ cancer.
death due to ____

colon;
HF

17

posterior pit:
ADH is synthesised in the ____.
oxytocin is synthesized in the ____;
both are transported to the posterior pit via ____

supraoptic nuclei;
paraventricular nuclei;
neurophysins

18

ADH release is stimulated by ____osmolality, ____volemia, and nausea

hyper, hypo

19

SIADH:
characterized by ___volemic ___natremia with ____ urinary Na exretion

euvolemic hyponatremia;
continued

20

in SIADH:
Urine osmolality is _____ than serum osmolality.
with water retention, aldosterone levels ____ and ____ levels increase

greater;
decrease, ANP/BNP

21

treatment of SIADH:
first, _____;
_____ is a arginine vasopressin receptor antagonist. ____ is a selective V2 receptor antagonist

water restriction;
conivaptan, tolvaptan

22

SIADH:
from ectopic ADH such as ____ cancer;
CNS disorders/trauma;
____ disease

small cell lung;
pulmonary

23

DI:
urine osmolality is ____ than serum osmolality;
___natremia, polyuria, polydipsia.
specific gravity is (low or high)
hyperosmotic volume _____

lower;
hyper;
low;
contraction

24

DI:
with central DI, ADH levels are _____. with nephrogenic, ADH levels are ____, which responds to exogenous ADH?

low;
normal or high;
central