Flashcards in Lecture 4 - Lipid Probs Deck (23):
____ releases free fatty acids from lipoproteins and chylomicrons
lipoproteins:____ is secreted by the liver and delivers TGs to peripheral tissue.
VLDL; TG depleted source = IDL
lipoproteins:____ is secreted by the liver and intestine and transports cholesterol from the periphery to the liver. this process is called ____
HDL, reverse cholesterol transport
lipoproteins:____ deliver dietary TG's to the peripheral tissues and liver. it is secreted by ____ cells
lipoproteins: LDL delivers ____ to the peripheral tissues and is the main transporter in the blood
apoliproteins: A1 produced in liver/intestine. which liporoteins have this? What does it do?
HDL, chylomicrons;mediates reverse cholesterol tranpsort (activates LCAT)
apolipoproteins: Apo B100 is produced where? what is it found on ? what does it do?
liver;VLDL, IDL, LDL;binds LDL receptor
apolipoproteins:____ is found only in chylomicrons and is produced in the small intestine. what does it do?
ApoB48; mediates chylomicron secretion
Apolipoproteins: ApoE is found on what lipoproteins?What does it do? Produced in liver and intestine
all except LDL;mediates chylomicron remnant uptake
ApoCII is found on what lipoproteins? What is its function?
chylomicrons, VLDL, HDL;LPL cofactor (ie binds LPL and activates it)
what lipoprotein is involved in the exogenous pathway of lipid metabolism?
what enzyme catylyzes esterifcation of cholesterol?
what does CETP do?
mediates transfer of cholesterol esters to other lipoproteins
what lipoprotein ratio is key to assessing risk of coronary vascular disease? what is the ratio?
total cholesterol : HDL cholesterol;values over 4.5 are concerning
familial hypercholesterolemia is a ____ disorder caused by absent or defective ______ or a defect in apo____
LDL receptors; b100
characterized by increased ____ and _____ levels. accelerated ____, tendon ____, and corneal _____
____ disorder, caused by defeciency in ____ or _____. see increased _____, ____, and _____
chylomicrons, TGs, cholesterol
see ____ xanthomas, recurrent _____, hepatosplenomegaly
tangier disease =
familial ____ deficiency;
see large yellow ____, increased risk CAD
friedewald equation for LDL:
total cholesterol - HDL - (TG/5)
what does the framingham calculator predict?
chance of heart attack in next 10 years
in a patient with 0-1 risk factor, therapy should be initiated when LDL is above:
what about one with CHD?