Lecture 4 - Lipid Probs Flashcards Preview

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Flashcards in Lecture 4 - Lipid Probs Deck (23):
1

____ releases free fatty acids from lipoproteins and chylomicrons

lipoprotein lipase

2

lipoproteins:____ is secreted by the liver and delivers TGs to peripheral tissue.

VLDL; TG depleted source = IDL

3

lipoproteins:____ is secreted by the liver and intestine and transports cholesterol from the periphery to the liver. this process is called ____

HDL, reverse cholesterol transport

4

lipoproteins:____ deliver dietary TG's to the peripheral tissues and liver. it is secreted by ____ cells

chylomicrons;intestinal epithelial

5

lipoproteins: LDL delivers ____ to the peripheral tissues and is the main transporter in the blood

cholesterol

6

apoliproteins: A1 produced in liver/intestine. which liporoteins have this? What does it do?

HDL, chylomicrons;mediates reverse cholesterol tranpsort (activates LCAT)

7

apolipoproteins: Apo B100 is produced where? what is it found on ? what does it do?

liver;VLDL, IDL, LDL;binds LDL receptor

8

apolipoproteins:____ is found only in chylomicrons and is produced in the small intestine. what does it do?

ApoB48; mediates chylomicron secretion

9

Apolipoproteins: ApoE is found on what lipoproteins?What does it do? Produced in liver and intestine

all except LDL;mediates chylomicron remnant uptake

10

ApoCII is found on what lipoproteins? What is its function?

chylomicrons, VLDL, HDL;LPL cofactor (ie binds LPL and activates it)

11

what lipoprotein is involved in the exogenous pathway of lipid metabolism?

chylomicrons

12

what enzyme catylyzes esterifcation of cholesterol?

LCAT

13

what does CETP do?

mediates transfer of cholesterol esters to other lipoproteins

14

what lipoprotein ratio is key to assessing risk of coronary vascular disease? what is the ratio?

total cholesterol : HDL cholesterol;values over 4.5 are concerning

15

familial hypercholesterolemia is a ____ disorder caused by absent or defective ______ or a defect in apo____

AD;
LDL receptors; b100

16

familial hypercholesterolemia:
characterized by increased ____ and _____ levels. accelerated ____, tendon ____, and corneal _____

LDL, cholesterol;
atherosclerosis;
xanthomas, arcus

17

hyperchylomicroneemia:
____ disorder, caused by defeciency in ____ or _____. see increased _____, ____, and _____

AR;
LPL, ApoCII;
chylomicrons, TGs, cholesterol

18

chylomicronemia:
see ____ xanthomas, recurrent _____, hepatosplenomegaly

eruptive/pruritic;
pancreatitis

19

tangier disease =
familial ____ deficiency;
see large yellow ____, increased risk CAD

HDL;
tonsils

20

friedewald equation for LDL:

LDL =

total cholesterol - HDL - (TG/5)

21

what does the framingham calculator predict?

chance of heart attack in next 10 years

22

in a patient with 0-1 risk factor, therapy should be initiated when LDL is above:

what about one with CHD?

190 mg/dL;

130 mg/dL

23

normal TG = less than ____
normal HDL = greater than _____

150, 50