Lecture 9 Flashcards Preview

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Flashcards in Lecture 9 Deck (19):
1

Once pyruvate is produced, where is it transported?

Mitochondrion

2

The Krebs cycle is part of...

Substrate level phosphorylation

3

What is the first step of the oxidation of pyruvate?

Decarboxylation: COO- group forms CO2

4

The oxidation of pyruvate is carried out by...

pyruvate dehydrogenase enzyme complex

5

What is the second step of the oxidation of pyruvate?

reduction: NAD+ ---> NADH

6

What is the third step?

the remaining acetyl group is transferred to the molecule coenzyme A

7

Through which bond is the acetyl group transferred to the coenzyme A?

acetyl thioester bond

8

Energy is required for the third step, where does it come from?

the redox reaction in the second step

9

What does the oxidation of pyruvate yields?

1 co2, 1 NADH, 1 acetyl CoA molecule

10

Where does the Krebs cycle takes place?

mitochondrial matrix

11

Step 1 of Krebs cycle...

Condensation: oxaloacetate + acetyl group form citrate

12

Step 2-3 of Krebs cycle...

Isomerization: citrate is transformed into isocitrate by removing and adding water

13

step 4 of Krebs cycle...

first oxidation: NAD+ >>> NADH

14

Step 5 of Krebs cycle...

second oxidation NAD+ >>> NADH

15

Step 6 of Krebs cycle...

substrate level phosphorylation: GTP can transfer a phosphate to ADP

16

Step 7 of Krebs...

Third oxidation FAD >>> FADH2

17

What does the Krebs cycle yields?

1 ATP, 2 CO2, 3 NADH, 1 FADH2

18

What is yield for 1 glucose?

2 FADH2, 10 NADH, 4 ATP BUT 30 ATP AFTER CHEMIOSMOSIS

19

What is chemiosmosis?

The energy released by the transport allows for the formation of ATP from ADP and inorganic phosphate