Lipoproteins I and II Flashcards Preview

Biochemistry Post Midterm > Lipoproteins I and II > Flashcards

Flashcards in Lipoproteins I and II Deck (44):
1

how are lipids transported?

transport proteins
majority transported inside lipoproteins (large amounts of TAGS and cholesteryl esters)

2

how are lipids transported?

transport proteins
majority transported inside lipoproteins (large amounts of TAGS and cholesteryl esters)

3

what does albumin transport? what does it not transport?

lipids
not cholesterol!

4

how are lipids bound to albumin?

non-covalently

5

what do lipoproteins transport large amounts of?

TAGS and CE in the inner core

6

what type of plasma membrane does lipoproteins have?

monolayer made of phosphatidylcholine (lecithin) and free cholesterol

7

what has the highest amount of TAGS in lipoproteins?

cylomicrons

8

VLDLs are released by the liver directly into what?

blood

9

what leads to high cholesterol in blood?

cylomicrons
VLDL

10

how are LDLs formed?

in bloof from VLDLs

11

what the highest percentage of cholestryl esters and cholesterol in lipoproteins?

LDLs

12

What are the smallest lipoproteins?

HDL

13

what is HDL -2 rich in?

proteins, apolipoproteins

14

what is LPL?

extracellular enzyme mainly bound to capillary walls of heart, skeletal muscle and adipose tissue

15

how is LPL anchored?

heparan sulfate!

16

What does LPL do?

cleave TAGS inside of lipoproteins (chylomicrons) and VLDL (also rich in TAGS)

17

what does LPL need for activation?

Apo C-II

18

What do chylomicrons obtain in blood from HDL?

Apo C-II and apo E

19

Where is Apo B 48 synthesized and what is it needed for?

intestinal muscosal cell
release of chylomicrons into lymph

20

how does Apo b 48 and Apo B 100 happen?

mRNA editing

21

which LDL is considered to be a risk for CHD?

LDL-B

22

what does albumin transport? what does it not transport?

lipids
not cholesterol!

23

how are lipids bound to albumin?

non-covalently

24

what do lipoproteins transport large amounts of?

TAGS and CE in the inner core

25

what type of plasma membrane does lipoproteins have?

monolayer made of phosphatidylcholine (lecithin) and free cholesterol

26

what has the highest amount of TAGS in lipoproteins?

cylomicrons

27

VLDLs are released by the liver directly into what?

blood

28

what leads to high cholesterol in blood?

cylomicrons
VLDL

29

how are LDLs formed?

in bloof from VLDLs

30

what the highest percentage of cholestryl esters and cholesterol in lipoproteins?

LDLs

31

What are the smallest lipoproteins?

HDL

32

what is HDL -2 rich in?

proteins, apolipoproteins

33

what is LPL?

extracellular enzyme mainly bound to capillary walls of heart, skeletal muscle and adipose tissue

34

how is LPL anchored?

heparan sulfate!

35

What does LPL do?

cleave TAGS inside of lipoproteins (chylomicrons) and VLDL (also rich in TAGS)

36

what does LPL need for activation?

Apo C-II

37

What do chylomicrons obtain in blood from HDL?

Apo C-II and apo E

38

Where is Apo B 48 synthesized and what is it needed for?

intestinal muscosal cell
release of chylomicrons into lymph

39

how does Apo b 48 and Apo B 100 happen?

mRNA editing

40

which LDL is considered to be a risk for CHD?

LDL-B

41

what is hyperlipidemia Type II a characterized by?

high LDL

42

what is hyperlipidemia Type II b characterized by?

high LDL
high VLDL

43

what form of app b does intestinal muscosa form?

Apo B 48

44

what form a Apo B does liver cells form?

Apo B 100