Liver Function Test Flashcards Preview

Biochemistry Post Midterm > Liver Function Test > Flashcards

Flashcards in Liver Function Test Deck (42):
1

what type of test is liver function tests (LFT)?

combination of biochemical tests (a panel of tests)

2

what are spinder angioma, palmar erythema, and gynecomastia due to?

increased conversion of the testosterone to estrogen - stigmata of chronic cirrhosis

3

what does the LFT test for?

excretory function
serum enzyme levels
synthetic function
metabolic function

4

increase in total serum bilirubin
increase in conjugated bilirubin
increase in unconjugated bilirubin

hepatitis

5

increase in only conjugated bilirubin?

intrahepatic cholestasis

6

what are the two types of disorders in liver?


cholestasis
- intrahepatic - inflammation fo hepatocytes --> compression od CBD/chronic liver cancer
-extrahepatic cholestasis - gall stone or tumor blocking CBD

7

when may serum conjugated bilirubin be elevated?

in intra or extra hepatic cholestasis

8

what do the enzyme levels in serum tell you?

whether the disease is hepatocellular or cholestasis
extent of damage

9

what are the two aminotransferases (transaminases) in hepatocellular injury?

ALT
AST

10

which specifically increases with acute liver disease?

ALT

11

what does a ratio of AST:ALT 2:1 indicate?

long standing alcohol cirrhosis

12

what 3 tissues secrete ALP?

biliary canaliculi
placenta
osteoblasts from bone

13

what are the enzymes that indicate chlestasis?

ALP
GGT

14

what does elevated GGT and ALP indicate?

biliary stasis (intra or extra hepatic)

15

what does elevated ALP and no GGT indicate?

cause of elevated ALP is non-hepatic - bone, placenta etc.

16

What does elevated GGT and no ALP indicate?

recent alcohol or drug use

17

what is it when biliary tree is dilated?

extrahepatic cholestasis

17

what is it when biliary tree is not dilated?

intrahepatic cholestasis

18

what is long standing chronic liver disease characterized by?

low serum albumin = edema

18

what two things cause ascities?

portal hypertension
hypoalbuminemia

19

what does the synthetic function of liver test tell you?

if the disease is chronic or of short duration

19

when is the gamma band usually elevated?

with cirrhosis

20

which clotting factors require vitamin K?

2,7,9,10

20

what 2 things contribute to increase prothrombin time?

reduced synthesis of clotting factors
reduced gamma carboxylation because of low vitamin K

or a combination of both

21

what levels increase in end stage liver disease?

blood ammonia levels rise - impairment of urea formation by the liver

21

what is fatty liver?

excessive deposition of TAG in liver

22

what does AFP levels tell you?

tumor marker for patients with liver cancer

22

what can serum iron, transferrin and ferritin tell you?

hemochromatosis

23

what can ceruloplasmin levels tell you?

wilson's disease

23

which clotting factors require vitamin K?

2,7,9,10

24

what 2 things contribute to increase prothrombin time?

reduced synthesis of clotting factors
reduced gamma carboxylation because of low vitamin K

or a combination of both

24

what 2 things contribute to increase prothrombin time?

reduced synthesis of clotting factors
reduced gamma carboxylation because of low vitamin K

or a combination of both

25

what levels increase in end stage liver disease?

blood ammonia levels rise - impairment of urea formation by the liver

25

what levels increase in end stage liver disease?

blood ammonia levels rise - impairment of urea formation by the liver

26

what is fatty liver?

excessive deposition of TAG in liver

26

what is fatty liver?

excessive deposition of TAG in liver

27

what does AFP levels tell you?

tumor marker for patients with liver cancer

27

what does AFP levels tell you?

tumor marker for patients with liver cancer

28

what can serum iron, transferrin and ferritin tell you?

hemochromatosis

28

what can serum iron, transferrin and ferritin tell you?

hemochromatosis

29

what can ceruloplasmin levels tell you?

wilson's disease

29

what can ceruloplasmin levels tell you?

wilson's disease