Lung Cancers Flashcards
(23 cards)
pneumonic “coin” lesion on X-ray film or noncalcified nodule on CT
Lung Cancer
Lung Cancer complications
SPHERE: SVC Syndrome; Pancoast tumor; Horner Syndrome; Endocrine (paraneoplastic); Recurrent Laryngeal Symptoms (hoarseness); Effusions (pleural or pericardial)
Central Lung Cancers
Squamous and Small Cell Carcinomas
Most common lung cancer in nonsmokers
Adenocarcinoma Lung CA
Location of Adenocarcinoma Lung CA
Peripheral
Activating mutations associated with Adenocarcinoma Lung CA
k-ras; EGFR and ALK
Hypertrophic osteoarthropathy (clubbing)
Adenocarcinoma Lung CA
Lung cancer that grows along alceolar septa causing apparent thickening of alveolar walls
Adenocarcinoma Lung CA
Keratin pearls and intercellular bridges
Squamous Cell Carcinoma of Lung
Cancer that may produce ACTH, ADH, or antibodies against presynaptic calcium channels (Lambert-Eaton)
Small Cell (oat cell) Carcinomar
Cavitation, Cigarettes, hyperCalcemia
Squamous Cell Carcinoma of Lung
Produces PTHrP
Squamous Cell Carcinoma of Lung
Kulchitsky cells
small dark blue cells; associated with Small cell (oat cell) carcinoma
Pleomorphic giant cells found in ther Periphery of lung (occasionally central lung)
Large cell carcinoma
Chromogranin A (+)
Bronchial carcinoid tumor; it stains Nest of neuroendocrine cells
Carcinoid Syndrome
Serotonin secretion; flushing, diarrhea, wheezing
Tx of carcinoid Syndrome
Octreotide; somtostatin analog
Malignancy of the pleura associated with asbestos
Mesothelioma
Result of Mesothelioma
hemorrhagic pleural effusions and pleural thickening
Carcinoma that affects the apex of the lung
Pancoast tumor
IL ptosis, miosis, and anhidrosis
Horner Syndrome; if Pancoast tumor compresses the cervical sympathetic plexus; SVC syndrome; sensorimotor deficits and hoarseness
Pacial Plethora
SVC syndrome, impaired blood drainage from head
1 area lung cancers like to metastasize to
Adrenals
