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First Aid Respiratory > Pharmacology > Flashcards

Flashcards in Pharmacology Deck (26):
1

1st generation H1 blockers

Diphenhydramine, dimenhydrinate, chlorpheniramine

2

Used for Allergy, Motion sickness, Sleep Aid

Diphenhydramine, dimenhydrinate, chlorpheniramine

3

2nd generation H1 blockers

Loratidine, Fexofenadine, Desloratadine, Cetirizine

4

Benefits of 2nd generation over 1st generation H1 blockers

Less sedation

5

Expectorant; thins respiratory secretions; does not suppress cough

Guaifenesin

6

Mucolytic; can loosen mucous plugs in CF patients. Also an antidote for acetaminophen overdose

N-acetylcystine

7

Antitussive (antagonistizes NMDA glutamate receptors); Synthetic codeine analog

Dextromethorphan

8

Sympathomimetic alpha-agonist, nonprescription nasal decongestant

Pseudoephedrine, Phenylephrine

9

Reduce hyperemia, edema, and nasal decongestion, open obstructed eustachian tubes

Pseudoephedrine, phenylephrine

10

Illlicitly used to make methamphetamine

Pseudoephedrine

11

Nasal decongestant that can cause CNS stimulation/anxiety

pseudoephedrine

12

Toxicity of Pseudoephedrine, phenylephrine

HTN

13

Relaxes bronchial smooth muscle (beta-2) during acute exacerbation

Albuterol

14

Long-acting agents for prophylaxis of asthma

Salmeterol, Formoterol

15

S/E of Salmeterol and Formoterol

Tremor and arrhythmia

16

Likely causes bronchodilation by inhibiting phosphodiesterase, increasing cAMP levels due to decrease cAMP hydrolysis.

Theophylline (a methylxanthine)

17

Blocks actions of adenosine

Theophylline (a methylxanthine)

18

Usage is limited because of narrow therapeutic index; cardiotoxicty and neurotoxicity

Theophylline (a methylxanthine)

19

competitive block of muscarinic receptors; preventing bronchoconstriction, used for COPD

Ipratropium and tiotropium

20

Inactivate NF-KB, that transcription factor that induces the production of TNF-alpha and other inflammatory agents; 1st line therapy for chronic asthma

Corticosteroids like Beclomethasone, Fluticasone

21

Blocks leukotriene receptors; Good for aspirin induced asthma

Montelukast, Zafirlukast

22

5-lipoxygenase pathway inhibitor, blocks conversion of arachidonic acid to leukotrienes

Zileuton

23

Monoclonal anti-IgE antibody; blocks serum IgE from binding FceRI

Omalizumab

24

Used in allergic asthma resistant to inhaled steroids and long-acting beta2-agonist

Omalizumab

25

Muscarinic receptor agonist used in bronchial provocation challenge to help diagnose asthma

Methocholine

26

Used to treat pHTN; competitively antagonizes endothelin-1 receptors, decreases pulmonary vascular resistance

Bosentan