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Flashcards in Pharm-One Liners Deck (14):
1

A class of endogenous substances that include histamine, serotonin, prostaglandins, and vasoactive peptides that work in autocrine or paracrine manner

Autacoids

2

Two peptide that increase capillary permeability and edema

Bradykinin and histamine

3

Distribution of histamine receptors H1, H2, and H3

Smooth muscle and mast cells; stomach, heart, and mast cells; nerve endings, CNS respectively

4

Most common side effect of 1st generation antihistamines

Sedation, anticholinergic

5

1st generation antihistamine that is highly sedating

Diphendydramine

6

1st generation antihistamine that is least sedating

Chlorpheniramine

7

Major indication for H1 antihistamines

IgE mediated allergic reaction (allergic rhinitis, urticaria)

8

Antihistamine that is indicated for allergies, motion sickness, and insomnia

Diphenhydramine

9

Antihistamine with motion sickness as the only indication

Dimenhydrinate

10

Three 2nd generation antihistamines

Fexofenadine, loratadine, and cetirizine

11

H2 antagonist that causes the most interactions with other drugs

Cimetidine

12

Indication for H2 antagonists

Acid reflux disease, duodenal ulcer and peptic ulcer disease

13

Mechanism of action of cromolyn

Prevent mast cell degranulation (by blocking opening of Cl- channels)

14

Enzyme which theophylline inhibits

Phosphodiesterase