Flashcards in Lymph Nodes Deck (343)
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301
Nodular-sclerosis Hodgkin's lymphoma: Immunohistochemistry (4,2).
Positive: CD30, CD15, Pax-5, Mum-1.
Negative: CD45, EMA.
302
Nodular-sclerosis Hodgkin's lymphoma: Expression of CD20.
Usually negative but may be weak in some of the tumor cells in some cases.
303
Nodular-sclerosis Hodgkin's lymphoma: Expression of Oct-2 and Bob.1.
One or the other is positive, but not both.
304
Nodular-sclerosis Hodgkin's lymphoma: Expression of EBV.
Detectable by EBER in 10-40% of cases.
305
Nodular-sclerosis Hodgkin's lymphoma vs. HL of mixed-cellularity type.
Mixed-cellularity type:
- Inconspicuous or absent fibrous bands.
- Much stronger association with EBV.
306
Nodular-sclerosis Hodgkin's lymphoma vs. PTCL, NOS with true Reed-Sternberg cells.
In the latter, the T cells are morphologically (usually) and immunophenotypically aberrant.
307
Nodular-sclerosis Hodgkin's lymphoma vs. reactive immunoblasts.
Reactive immunoblasts express CD30 but not CD15.
308
Nodular-sclerosis Hodgkin's lymphoma: Best place to look for Reed-Sternberg cells.
Around the necrotic areas.
309
Mixed-cellularity Hodgkin's lymphoma:
A. Associations (3).
B. Median age at presentation.
A. Male sex, HIV, residence in developing country.
B. 38 years (older than that of NS-CHL).
310
Mixed-cellularity Hodgkin's lymphoma:
A. Most common site.
B. Prognosis.
A. Cervical lymph nodes; rarely involves mediastinum.
B. Excellent.
311
Mixed-cellularity Hodgkin's lymphoma: Immunohistochemistry.
Same as that of NS-CHL.
312
Lymphocyte-rich Hodgkin's lymphoma:
A. Median age.
B. Gender predilection.
A. Older than that of other subtypes of CHL.
B. Mainly affects males.
313
Lymphocyte-rich Hodgkin's lymphoma:
A. Typical site.
B. Prognosis.
A. Cervical lymph nodes; rarely involves mediastinum.
B. Excellent.
314
Lymphocyte-rich Hodgkin's lymphoma: Histology (4).
Small lymphocytes form nodules that contain
- Small regressed germinal centers.
- Scattered Reed-Sternberg cells.
- Few or no granulocytes.
315
Lymphocyte-rich Hodgkin's lymphoma: Immunohistochemistry of tumor cells.
Same as that of NS-CHL.
316
Lymphocyte-rich Hodgkin's lymphoma: Other immunohistochemistry (2).
Small lymphocytes are mantle cells that express IgD.
Small regressed germinal centers express CD21 and CD23.
317
Lymphocyte-rich Hodgkin's lymphoma: Association with EBV.
Detectable by EBER in about half of cases.
318
Langerhans'-cell histiocytosis: Age group of peak incidence.
One to three years.
319
Langerhans'-cell histiocytosis: Pattern of infiltration.
Sinusoidal.
320
Langerhans'-cell histiocytosis: Cellular components.
Langerhans' cells.
Eosinophils, neutrophils, small lymphocytes.
321
Langerhans'-cell histiocytosis: Cytology of tumor cells.
Nuclei: Irregular; nuclear groove sometimes; inconspicuous nucleolus.
Cytoplasm: Ill-defined, acidophilic.
322
Langerhans'-cell histiocytosis: Immunohistochemistry (3).
S100: All Langerhans' cells.
CD1a, langerin: Some Langerhans' cells..
323
Langerhans'-cell histiocytosis: Mutation.
V600E in BRAF in about half of cases.
324
Langerhans'-cell histiocytosis vs. Rosai-Dorfman disease (3).
Rosai-Dorfman disease:
- Large nucleoli.
- Emperipolesis.
- Absence of CD1a and langerin (but S100 is expressed).
325
Langerhans'-cell histiocytosis vs. dermatopathic lymphadenopathy (2).
Dermatopathic lymphadenopathy:
- Paracortical, not sinusoidal, infiltrate.
- Langerhans' cells are not accompanied by granulocytes or plasma cells.
326
Langerhans' cells:
A. Functions (2).
B. Origin.
A. Antigen presentation, phagocytosis.
B. The skin.
327
Mixed-cellularity Hodgkin's lymphoma: Histology.
Similar to that of NS-CHL, but without broad bands of collagen.
328
Kaposi's sarcoma: Locations in the lymph node (4).
Early:
- Capsule.
- Hilum.
- Fat around the node.
Late: Entire node may be replaced.
329
Kaposi's sarcoma: Immunohistochemistry (5).
Positive: CD34, CD31, ERG, FVIII-related antigen, LANA (HHV8).
330
