Flashcards in Lymph Nodes Deck (343)
Kikuchi's disease: Typical presentation.
Cervical lymphadenopathy and fever.
Kikuchi's disease: Histologic phases.
Kikuchi's disease: Histology of the proliferative phase (3).
Patchy nodal disease.
Paracortical expansion with immunoblasts, small lymphocytes, plasmacytoid dendritic cells, histiocytes.
Single-cell necrosis and granular débris.
Kikuchi's disease: Histology of the necrotizing phase (4).
Extensive necrosis with karyorrhexis.
Immunoblasts and histiocytes surround necrosis.
Histiocytes with crescentic nuclei.
Kikuchi's disease: Histology of the resolution phase.
Many foamy macrophages.
Kikuchi's disease: Immunohistochemistry.
Plasmacytoid dendritic cells are reactive for CD123.
Very few B cells outside the germinal centers.
Kikuchi's disease: Relationship to systemic lupus erythematosus (2).
Similar histologic features.
Some patients with Kikuchi's disease develop lupus.
Kikuchi's disease: Prognosis.
Lymphadenitis of Kawasaki's disease: Histology (3).
Widespread necrosis with many neutrophils.
Fibrin thrombi in small vessels.
Arteritis with fibrinoid necrosis.
Lymphadenitis of systemic lupus erythematosus: Presentation (2).
Lymph nodes are soft and nontender.
Occurs at the onset of the disease or during an exacerbation.
Lymphadenitis of systemic lupus erythematosus: Histology (5).
Edema, hemorrhage, and necrosis surrounded by histiocytes and immunoblasts.
May show many plasma cells.
May show hematoxylin bodies.
May show the Azzopardi phenomenon.
May show marked follicular hyperplasia.
Tuberculous lymphadenitis: Most common site.
Cervical lymph nodes.
Tuberculous lymphadenitis: Causes of abdominal disease (2).
Ingestion of sputum or milk infected by M. tuberculosis or M. bovis.
Tuberculous lymphadenitis: Type of granuloma.
Usually caseating but can be non-necrotizing.
Atypical mycobacterial lymphadenitis: Causes (5).
Mycobacterium avium complex.
Atypical mycobacterial lymphadenitis: Typical immunocompetent patient.
Child of 1 to 5 years.
Atypical mycobacterial lymphadenitis: Typical site.
Atypical mycobacterial lymphadenitis: Histology in the immunocompetent
Necrotizing and non-necrotizing granulomas with Langhans' -type giant cells.
Atypical mycobacterial lymphadenitis: Histology in the immunocompromised (2).
Poorly organized aggregates of histiocytes.
Rare: Mycobacterial pseudotumor consisting of foamy and spindled histiocytes.
Atypical mycobacterial lymphadenitis: Treatment in the immunocompetent.
Leprosy: Countries of highest incidence.
Lepromatous leprosy: Histology.
The paracortical area contains many foamy macrophages that are full of organisms.
Inflammatory pseudotumor of the lymph node: Infectious causes (3).
Atypical mycobacteria, Treponema pallidum, or EBV is detected in some cases.
Cat-scratch disease: Acquisition (3).
Cat-scratch disease: Presentation.
Tender nodes with overlying erythema.
Cat-scratch disease: Atypical presentation (3).
Cat-scratch disease: Histology of the early stage (4).
Hyperplasia of monocytoid B cells.
Small foci of necrosis among monocytoid B cells.
Microabscesses in the germinal centers.
Cat-scratch disease: Histology of the late stage (2).
Large, stellate microabscesses.
Necrotizing granulomas with palisading histiocytes.
A. Typical locations in the lymph node (3).
B. Best stains (2).
A. Macrophages, endothelial cells, areas of necrosis.
B. Warthin-Starry, Steiner's.