Flashcards in Major DNA Viruses Deck (56)
Describe the characteristics of Parvovirus: B19.
How is parvovirus transmitted?
What is the pathogenesis of parvovirus B19?
infects mitotically active erythroid precursor cells in bone marrow
1. lytic: viremia, flu-like symptoms, viral shedding
2. non-infectious immune response
What are the clinical manifestations of parvo?
lacy reticular maculopapular rash
What are complications of parvovirus B19?
intrauterine infection may lead to hydrops fetalis
Describe the characteristics of Adenovirus.
How are adenoviruses transmitted?
- inhalation of respiratory droplets
- across eye by direct contact
What is the pathogenesis of adenoviruses?
-infect mucoepithelium in tissues
- infect adenoids, tonsils, respiratory epithelium, Peyer's patches, intestinal epitheia
Which Ig is involved to resolve adenovirus?
Adenovirus proteins interfere with immune defenses by blocking ?
Adenovirus has what oncogenes?
promote cell growth
EIA >> inactivates pRB (retinoblastoma)
E1B>> inactivates p53
What are the clinical syndromes of Adenovirus infection?
Acute Febrile Pharyngitis
Acute respiratory disease
Other: laryngitis, croup, brionchiolitis
Epidemic karatoconjunctivitis "shipyard eye"
Acute gastroenteritis (infants)
What are the characteristics of papillomaviridae (HPV)?
What is the incubation period for papillomaviridae (HPV)?
2 weeks to 1+ years
What are common diseases of papillomaviridae (HPV)?
anogenital warts (HPV 6/11)
Cervical cancer (HPV16/18)
What layer of the skin does papillomaviridae (HPV) develop?
basal cells of the dermal layer via L1 VAP/integrins
What are epithelial spikes referred to as?
In what layer are prickle cells present? prickle layer?
In papillomaviridae (HPV), E6 binds to ___________ and activates ___________ and suppresses ____________.
in papillomaviridae (HPV) E7 binds to ___.
What laboratory tests would you use to diagnose papillomaviridae (HPV)?
Cytology: Koilocytotic cells
In situ DNA probe analysis
What is the treatment of papillomaviridae (HPV)?
-interferon, imiquimod or stripping with duct tape
What vaccinations are available for papillomaviridae (HPV)?
Gardasil (tetravalent HPV6,11,16,18)
Cervarix (divalent HPV16,18)
9-26 years of age
3 doses (initial, 2 mos, 6 mos)
What are the characteristics of herpesvirus (HSV, VZV)?
How is herpesvirus (HSV, VZV) transmitted?
requires inoculation of virus-containing body fluids
sites: oral, ocular, genital, mucosa, respiratory tract, blood stream
What are the clinical presentations of HSV-1?
lesions on oropharynx
What are the clinical presentation of HSV-2?
lesions on genitalia
(can be spread without genital lesions)
Where do herpesvirus (HSV, VZV) go latent?
How are HSV 1/2 transmitted?
How is VZV transmitted?
What are primary manifestation of HSV-1?
gingiovostomatitis - children(fever, malaise, lesions)
pharyngitis or tonsillitis - adults
What are secondary/recurrent manifestations of HSV-1?
Herpatic Whitlow (fingers)
What are 3 separate phases of HSV?
What triggers can reactivate HSV?
How is recurrence suppressed for HSV?
strong cellular immune response
HSV-1 can be responsible for (encephalitis/meningitis)?
What are some HSV complications?
(if immune suppressed - pneumonia, mucocutaneous lesions)
How would you diagnose HSV 1/2?
PCR of CSF for HSV encephalitis
Why is HSV difficult to prevent?
many people shed asymptomatically
What is the treatment for HSV?
In what form is VZV reactivated?
What can trigger VZV reactivation?
How would shingles present?
redness of dermatome
post-herpatic neuralgia (PHN) can be prolonged
How would you diagnose VZV?
3 types of lesions simultaneously
What treatments are available for VZV?
chicken pox - symptomatic
Zoster rash - acyclovir
Zoster PHN - tricycle antidepressant
What are the characteristics of poxviridae?
How is poxviridae transmitted?
How does poxviridae present?
basophilic inclusion bodies
What treatments are available for poxviridae?
What are the characteristics of Hepadnaviridae (HBV)?
How is Hepadnaviridae (HBV) transmitted?
***minute amount can transmit***
perinatal (during birth or through milk)
(once it enters bloodstream it travels to the liver to infect hepatocytes)
Describe replication of Hepadnaviridae (HBV)?
DNA virus but includes RNA intermediate
encodes reverse transcriptase (RNAd-DNA pol)
What are the clinical manifestations of Hepadnaviridae (HBV)?
excretion of bile pigments
-bilirubin accumulation (Jaundice)
During which phase of chronic HBV would treatment be an option?
(not indicated during immune tolerant or inactive phase)
What are the treatment options for Hepadnaviridae (HBV)?
Active vaccine (0,1,6 mos)
HBV immunoglobin (HBIG)