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Flashcards in Sepsis and Septic Shock Deck (10)
1

Define systemic inflammatory response syndrome (SIRS).

Response of the body systemically
- infection could be in blood or tissue
- could be do to an infection

Criteria:
Any 2 of the following
-fever of more than 38 degrees (or less than 36)
- heart rate > 90
- respiratory rate >20 breaths more minute
- abnormal WBS >12000/ul
- bands (immature neutrophil)

2

What is normal WBC?

4,000 - 10,000 / cmm

3

What is a band cell?

-immature neutrophil
- band cells increase in blood when need for neutrophils exceeds bone marrow's ability to produce them

4

What is the acute phase response?

Release of various proteins from liver in response to stimulation with IL-6 and other pro-inflammatory cytokines

5

What is sepsis?

SIRS due to a documented infection

6

What is severe sepsis?

sepsis with organ dysfunction
ex) elevated BUN, createnine, urinary problems

nonresponsive - organ dysfunction

7

What is septic shock?

infection-induced Hypotension and cannot be reversed with IV fluid

8

What is disseminated intravascular coagulation (DIC)?

systemic activation of clotting system followed by depletion of clotting factors and subsequent systemic hemorrhage

9

What is multiorgan dysfunction syndrome?

varying degrees of organ impairment secondary to SIRS

10

What is compensatory anti-inflammatory response syndrome (CARS)?

unregulated anti-inflammatory response leading to immune suppression & increased risk of infection