Male Reproductive Pharmacology Flashcards Preview

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Flashcards in Male Reproductive Pharmacology Deck (9)
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1
Q

testosterone is converted to dihydrotestosterone by _______ and to estradiol by _______

A

5alpha-reductase; aromatase

2
Q

cypionate: mechanism of action

A

testosterone ester: more lipophilic than testosterone, hydrolyzes in vivo

3
Q

stanozolol: mechanism of action, unique side effects

A

mechanism: 17-alpha alkylated testosterone, slower hepatic catabolism than testosterone
side effects: hepatotoxicity, decrease HDL

4
Q

what treatment regimen should be given to boys who have hypogonadism and are short?

A

treat with GH before their hypogonadism is treated with testosterone (testosterone may cause premature closure of epiphyseal plates)

5
Q

side effects of anabolic steroid abuse

A

all androgens suppress gonadotropin (LH) secretion when taken in high doses and thereby suppress endogenous testicular function –> gonadal atrophy, diminished fertility

6
Q

leuprolide: mechanism of action, uses, toxicity

A

mechanism: GnRH analog with agonist properties when used in pulsatile fashion; antagonist properties when used in continuous fashion (downregulates GnRH receptor in pituitary –> decreased FSH/LH)
uses: infertility (pulsatile), prostate cancer (continuous), uterine fibroids (continuous), precocious puberty (continuous)
toxicity: antiandrogen, N/V

7
Q

flutamide: mechanism of action, use

A

mechanism: androgen antagonist, nonsteroidal competitive inhibitor at androgen receptors
use: prostate carcinoma

8
Q

finasteride: mechanism of action, use

A

mechanism: 5alpha-reductase inhibitor
use: BPH, male pattern baldness

9
Q

drug class to treat erectile dysfunction, mechanism of action, side effects

A

PDE-5 inhibitors
mechanism of action: increases cGMP, smooth muscle relaxation in corpus cavernosum, increased blood flow
side effects: “Hot and sweaty, but Headaches, Heartburn, Hypotension” = headache, flushing, dyspepsia (indigestion), cyanopsia (blue-tinted vision), risk of life-threatening hypotension is patients taking nitrates