Flashcards in 1st Trimester Complications Deck (15):
what is the function of hCG and when does it peak during pregnancy?
promotes maintenance of the progesterone-secreting corpus luteum; peaks at 10 weeks gestation at about 100,000 mIU/mL
what are the implications for hCG's similarity with LH?
hCG it can be used to induce ovulation in the female ovary during fertility treatment as well as stimulate testosterone production in the male testes
mechanism of urine pregnancy test
employs monoclonal antibody specific to the beta subunit of hCG
what is the rate of increase of serum hCG during a normal pregnancy?
doubles every 48 hours
what is the discriminatory zone of hCG?
1500-2000 mIU/mL, when transvaginal ultrasound should be able to visualize the pregnancy
difference between inevitable and incomplete abortion
inevitable abortion is without passage of products of conception, whereas incomplete is partial passage of products of conception
what is a missed abortion?
intrauterine demise < 20 weeks without any passage of fetal or placental tissue
treatment for ectopic pregnancy
surgery or methotrexate
dx: extremely high hCG, snowstorm appearance on ultrasound
complete molar pregnancy
complete molar pregnancy: _____ proliferation, results from _____, paternally-derived _____ genotype
trophoblastic; fertilization of an enucleate egg; diploid
partial molar pregnancy: contains ____, arises from _____
fetal tissue; fertilization of a haploid ovum by two sperm or by a single sperm that then duplicates
complete moles: __ sets of genes (__ maternal, __ paternal), __ fetus
partial mole: __ sets of genes (__ maternal, __ paternal), __ fetus
complete: 2 (diploid); 0; 2; no
partial mole: 3 (triploid); 1; 2; non-viable
treatment for hyatidiform molar pregnancy and choriocarcinoma and its mechanism of action
methotrexate; binds to dihydrofolate reductase and interfere with DNA synthesis
dx: hCG fails to increase by at least 53% over 48 hours