1st Trimester Complications Flashcards Preview

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Flashcards in 1st Trimester Complications Deck (15):

what is the function of hCG and when does it peak during pregnancy?

promotes maintenance of the progesterone-secreting corpus luteum; peaks at 10 weeks gestation at about 100,000 mIU/mL


what are the implications for hCG's similarity with LH?

hCG it can be used to induce ovulation in the female ovary during fertility treatment as well as stimulate testosterone production in the male testes


mechanism of urine pregnancy test

employs monoclonal antibody specific to the beta subunit of hCG


what is the rate of increase of serum hCG during a normal pregnancy?

doubles every 48 hours


what is the discriminatory zone of hCG?

1500-2000 mIU/mL, when transvaginal ultrasound should be able to visualize the pregnancy


difference between inevitable and incomplete abortion

inevitable abortion is without passage of products of conception, whereas incomplete is partial passage of products of conception


what is a missed abortion?

intrauterine demise < 20 weeks without any passage of fetal or placental tissue


treatment for ectopic pregnancy

surgery or methotrexate


dx: extremely high hCG, snowstorm appearance on ultrasound

complete molar pregnancy


complete molar pregnancy: _____ proliferation, results from _____, paternally-derived _____ genotype

trophoblastic; fertilization of an enucleate egg; diploid


partial molar pregnancy: contains ____, arises from _____

fetal tissue; fertilization of a haploid ovum by two sperm or by a single sperm that then duplicates


complete moles: __ sets of genes (__ maternal, __ paternal), __ fetus
partial mole: __ sets of genes (__ maternal, __ paternal), __ fetus

complete: 2 (diploid); 0; 2; no
partial mole: 3 (triploid); 1; 2; non-viable


treatment for hyatidiform molar pregnancy and choriocarcinoma and its mechanism of action

methotrexate; binds to dihydrofolate reductase and interfere with DNA synthesis


dx: hCG fails to increase by at least 53% over 48 hours

ectopic pregnancy


dx: 43 year old female with heavy vaginal bleeding, urine pregnancy test is positive, ultrasound shows embryo without cardiac activity, cervix is open

inevitable abortion