Male Reproductive Physiology Flashcards Preview

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Flashcards in Male Reproductive Physiology Deck (13):
1

what cells secrete Mullerian inhibiting factor? what is the function of MIF?

Sertoli cells; suppresses development of paramesonephric (Mullerian) ducts

2

what cells secrete androgens? what is the function of androgens?

Leydig cells; stimulate development of mesonephric (Wolffian) ducts --> male phenotype

3

what does the mesonephric duct develop into in the male fetus?

mnemonic: SEED
male internal structures (except prostate): Seminal vesicles, Epididymis, Ejaculatory duct, Ductus deferens

4

what is the function of 5alpha-reductase?

converts testosterone to DHT (dihydrotestosterone)

5

why do men have circulating estrogens?

expression of aromatase in peripheral (particularly adipose) tissue

6

what enzyme converts testosterone to DHT (dihydrotestosterone) and why is this necessary?

5alpha-reductase; DHT has a higher affinity for androgen receptor in nucleus of target cells

7

what two hormones are major stimulators of spermatogenesis?

FSH and local testosterone

8

functions of testosterone (5)

1. differentiation of epididymis, vas deferens, seminal vesicles (genitalia, except prostate)
2. growth spurt: penis, seminal vesicles, sperm, muscle, RBCs
3. deepening of voice
4. closing of epiphyseal plates (via estrogen converted from testosterone)
5. libido

9

where is inhibin made and what is its function?

Sertoli cell; inhibits only FSH release from anterior pituitary

10

what hormone stimulates the Leydig cell and what is its main function?

LH; produces testosterone which has system androgenic effects and has local intra-testicular effects by diffusing into the Sertoli cell, increasing the response to FSH

11

what hormone stimulates the Sertoli cell and what is its main function?

FSH; stimulates spermatogenesis and makes inhibin

12

analogous cells in female and male gonads

leydig cell (testis) = theca interna cell (ovary)
Sertoli cell (testis) = granulosa cell (ovary)

13

androgen-binding protein: where is it made, what is its function

Sertoli cell; acts as a local "sink" for testosterone so that developing sperm are bathed in very high concentrations of testosterone