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what causes DAG accumulation in obese pts? what does this cause?

1. excessive caloric intake (increased lipid synthesis)
2. defects in adipocyte metabolism
3. defects in mitocondria function
4. gene variation in APO c3
5. reduced AMPK signaling



1. translocation of GLUT4 -> inhibiting insulin stimulated uptake of glucose

2. glycogen synthase *