Medication Administration Flashcards
(80 cards)
Pharmakinetics
study of absorption, distribution, metabolism, and excretion (ADME)
ionization
pH of the medication and the site of absorption; ionized: weak bases more readily absorbable in the small intestine
dissolution
meds must be dissolved before absorption takes place
surface area of the absorption site
size of the surface area where the meds will be absorbed
what facts can influence absorption
route of administration
ionization
dissolution
blood flow
lipid solubility
surface area of the absorption site
client-specific factors
between high and low lipid soluble meds, which will get absorbed faster
high lipid soluble meds
enteral route
meds administered via the mouth, stomach, or intestines
distribution
med delivery to the target after it has been absorbed into the circulatory system
what factors contribute to distribution
blood flow
solubility
protein binding ability
toxicity
body can’t metabolize or excrete a meds, can cause irreversible damage to organs
prodrugs
inactive chemicals that are activated through metabolism
which organ is the primary one for excretion
kidneys
factors that influence excretion
kidney, heart, and liver function
pharmacodynamics
how a medication works, its relationship to medication concentrations, and therapeutic range
what is therapeutic drug monitoring (TDM) method used for
monitor med concentration in pt’s blood; meds with a narrow therapeutic window
adverse drug event (ADE)
requires intervention to prevent death, permanent disability, or congenital anomaly, causes hospitalization; need to report to FDA
black box warning
on meds that may produce lethal and iatrogenic results
iatrogenic
unforesseable or unintended injury or disorder caused by the treatment or procedure
signs of allergic reaction
rash, hives, swelling, circulatory collapse, laryngeal edema
anaphylaxis symptoms
dyspnea, hypotension, and tachycardia
Steven Johnson syndrome (SJS) symptoms
respiratory distress, fever, chills, fine rash followed by blisters
high fat meals will decrease or increase the rate of absorption
decrease intestinal absorption
teratogenic
cause fetal defects, pregnancy loss, developmental disabilities, or prematurity
examples of teratogenic meds
cocaine, alcohol
angiotensin converting enzyme (ACE) inhibitors
gentamycin
lithium
NSAIDs
tetracycline