Membranoproliferative glomerulonephritis

Question 1

AKA

Answer 1

mesangiocapillary glomerulonephritis

Question 2

Which Type of membranoproliferative glomerulonephritis accounts for most cases? Type 1 or 2

Answer 2

Type 1

Question 3

Causes of Type 1 Membranoproliferative glomerulonephritis

Answer 3

cryoglobulinaemia
hepatitis C

Question 4

Findings of Type 1 membranoproliferative glomerulonephritis on renal biopsy

Answer 4

electron microscopy:
- subendothelial and mesangium immune deposits
- ‘tram-track’ appearance

Question 5

Causes of Type 2 Membranoproliferative GN

Answer 5

partial lipodystrophy
factor H deficiency

(both cause persistent activation of the alternative complement pathway)

Question 6

Signs of Type 2 GN on renal biopsy

Answer 6

electron microscopy:
- intramembranous immune complex deposits
- ‘dense deposits’

Question 7

Causes of Type 3 Membranoproliferative GN

Answer 7

Hep B and C

Question 8

Mainstay of Mx for Membranoproliferative GN

Answer 8

Steroids