Module 2 Cyclin/CDK complex

Question 1

Part 2:

RB is ____ and E2F activates the transcription of the ____ which binds to ____

Answer 1

Partially phosphorylated

CYCLIN E + CDK 2

Question 1

Part 1:

The first cyclin ____ binds to the ____ and ____ which Phosphorylates _____ that holds the ____

Answer 1

CYCLIN D + CDK 4 and CDK 6

Phosphorylates

RB, RETINOBLASTOMA TUMOR SUPPRESSOR PROTEIN + E2F

Question 2

Part 3:

____ fully phosphorylates RB, causing the entire separation of E2F

Answer 2

Cyclin E + CDK2

Question 3

Part 4:

Cyclin E + CDK2 phosphorylates the protein ___ which is supposed to inhibit ____

Simultaneously, the E2F removes the ____ which is a repressor

Both promotes the production of ____ leading into the ___

Answer 3

P27 KIP1
Cyclin D

Cell-cycle responsive element

Cyclin A
S Phase

Question 4

Part 5:

Cyclin A replaces ____ to bind to ____ to cause the S Phase to progress

The process above causes the production of ___ to cease

Cyclin A binds to ___ so M phase can progress

Answer 4

Cyclin E
CDK2

Pre-replication Complex

CDK 1

Question 5

Part 6:

Cyclin A phosphorylates ____

Eventually, late in the ___ Cyclin A is replaced by ____ signifying the end of mitosis

Answer 5

E2F

G2 Phase
Cyclin B

Question 6

Part 7:

Cyclin B binds to ____, which leads to what is called the ____

Answer 6

Cyclin B + CDK 1
Maturation/Mitosis Promoting Factor