Module 3e: Automation Flashcards

1
Q

The process whereby an analytical instrument, apparatus or system operates and performs many tests with only minimal involvement of an analyst or human intervention

A

Automation

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2
Q

Type of analysis in which many specimens are grouped in the same
analytical session.

A

Batch analysis

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3
Q

The transport of a quantity of analyte or reagent from one specimen reaction into and contaminating a subsequent one.

A

Carryovee

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4
Q

Type of analysis in which each specimen in a batch pass through the same continuous stream at the same rate and is subjected to the same analytical reactions.

A

Continuous flow analysis

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5
Q

Type of analysis in which the sample is aspirated into the sample probe and then is delivered, often with reagent, through the same orifice into a reaction cup or another container.

A

discrete analysis

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6
Q

Type of analysis in which each specimen is subjected to multiple analytical processes so that a set of test results is obtained on a single specimen

A

Multiple-channel analysis

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7
Q

Type of analysis in which all specimens are subjected to a series of analytical processes at the same time and in a parallel fashion.

A

Parallel analysis

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8
Q

The most common configuration of an automated analyzer, in which analyses are performed on a collection of specimens sequentially and each specimen is analyzed on a different selection of tests.

A

Random access analysis

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9
Q

Type of analysis in which each specimen in a batch enters the analytical process one after another, and each result or set of results emerges in the same order as the specimens are entered.

A

Sequential analysis

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10
Q

Type of analysis in which each specimen is subjected to a single process so that only results or a single analyte are produced

A

Single channel analysis

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11
Q

The number of specimens processed by an analyzer during a given period of time, rate of processes

A

throughput

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12
Q

Dedicated to a defined task and contains appropriate laboratory instrumentation to carry out that task.

A

workstation

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13
Q

Resolves the major consideration of uniformity in the performance of tests because each
sample follows the same reaction path.

A

Continuous flow

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14
Q

Advanatge of continuous flow approach

A

asssist laboratory that needs to run many samples requiring same procedure

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15
Q

disadvantages of continuous flow

A

waste of continuously flowing reagents

significant carry over problems

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16
Q

Utilizes the force generated by centrifugation to transfer and then contain liquids in separate cuvettes for measurement at the perimeter of a spinning rotor.

A

Centrifugal analysis

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17
Q

Major adavantage of Centrifugal analysis

A

batch analysis

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18
Q

most popular and versatile, and have almost completely replaced continuous-flow and centrifugal analyzer

A

Discrete analysis

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19
Q

Have the capability of running multiple tests one sample at a time or multiple samples one test at a time.

A

discrete analysis

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20
Q

Three basic approaches with instruments:

A

Continuous flow
Centrifugal analysis
Discrete analysis

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21
Q

The general steps employed in automated analyzers are collectively known as

A

unit operations

22
Q

The most sophisticated approach in sample identification that is commonly used today .

A

Bar code label

23
Q

Provide rapid specimen transportation and are reliable when installed as point-to-point services

A

Pneumatic Tube

24
Q

drawback of pneumatic tubes

A

misrouting of carriers

hemolysis due to acceleration

25
[specimen delivery] Have a larger carrying capacity than pneumatic tube systems and are not associated with problems such as damage to specimens caused by acceleration and/or deceleration forces
electric track devices
26
[specimen delivery] Easily adapted to carry specimen containers of various sizes and shapes and are reprogrammable with changes in laboratory geometry.
Mobile robots
27
[specimen preparation] the serum or plasma sample is placed in a tube after separation from blood clot then directly used for analysis without further transfer to nalyzer cup
Primary tube sampling
28
[Specimen preparation] Use whole blood for analysis to bypass the specimen preparation altogether
Abbott- Vision
29
[specimen preparation] pre-analytic automation system that can identify and label specimens, centrifuge the specimens and prepare aliquots, and sort and deliver samples to the analyzer or to storage
Front-end automation
30
[specimen measurement & internal delivery] Controls entry of the sampling probe to a minimal depth below the surface of the serum
parallel liquid level-sensing probe
31
How continuous flow probes prevent carryover and maintains sample integrity
1. probe aspirates air to produce bubble 2. probe descends into wash solution 3. wash solution is aspirated
32
[Reagent systems and internal delivery] Used to deliver liquid reagents
positive displacement syringe devices
33
[reagent system and internal delivery] Has three or more layers which include a spreading layer which accepts the sample, one or more central layer which can alter the sample by a series of chemical reactions, and an indicator layer where the analyte of interest may be quantified.
dry chemistry slide
34
consists of mixing, separation, incubation, and reaction time
chemical reaction phase
35
[Chemical reaction phase] Used by continuous flow analyzer in mixing
coiled tubing
36
[Chemical reaction phase] Used by centrifugal analyzer in mixing
centrifugal force
37
[Chemical reaction phase] Used by most wet chemistry analyzer in mixing
stirring paddles
38
Causes major interference in many analyses.
proteins
39
Used by continuous flow systems in separation
dialyzer
40
Usually used im incubatiom
water bath/ heating bath
41
Entails quantification of the formed products.
Measurement phase
42
[measurement phase] automated chemistry analyzers use
Optical measurement devices
43
[Signal processing and data handling] the analyte concentration is estimated using a
calibration curve
44
[Signal processing and data handling] involves
- Acquisition of response signal and signal averaging - Subtraction of black response - Correction of response for interferences - Linear regression for calibration curve and determining slope - computation of rate reactions
45
[Sending of Results to LIS] Laboratory-wide (often times hospital-wide) computer software system that records, manages, and stores data for clinical laboratories
Laboratory Information System
46
The combination of several instruments, consolidated instruments, work cells, integrated work cells, or integrated modular work cells coupled to a specimen management and transportation system, and control software component, to automate a large percentage of laboratory work
total laboratory automation
47
TLA approach are considered=
"Black Box labs"
48
Three components of a Black Box lab
Front end system analytic box Back end system
49
It is responsible for the pre-analytic phase/ sample processing.
front end systems
50
This is responsible for the chemical analyses/ analytic phase. It utilizes the basic principles of chemistry instrumentation
analytic box
51
It is responsible for the post-analytic phase (data management)
back end system