[Multiple Sclerosis] Flashcards Preview

NEUROLOGY > [Multiple Sclerosis] > Flashcards

Flashcards in [Multiple Sclerosis] Deck (25)
1

[MS]: ... levels relate to prevention of MS and fewer lesions in those already diagnosed

Vit D

2

[MS]: what is the ocular involvement

Unilateral optic neuritis

3

[MS]: What are the 4 main symptoms classical to MS

optic neuritis
Limbs numbness
Leg weakness
Diplopia/ataxia (brainstem/cerebellar involvement)

4

[MS]: Poor prognosis is associated with increased age, ... gender, early motor involvement and many lesions.

male

5

[MS]: Dx is clinical and is upon what observation

lesions disseminated in time and space unattributable to another cause

6

[MS]: How might an unnoticed previous demyelinating lesion manifest.

Brief period of visual disturbance, unexplained.

7

[MS]: What is the name of the set of criteria used for aiding Dx

McDonald

8

[MS]: What disease may also present with an inflammatory demyelination

Devic's syndrome
(aka neuromyelitis optica)

9

[MS]: Is Devics or MS associated with more severe attacks

Devics

10

[MS]: Where are the MRI cord lesions in MS

peripheral (multiple and small)

11

[MS]: In Devics where are the cord lesions

Continuous and long

12

[MS]: Devics is differentiated from MS by the detection of ... antibodies

Anti-AQP4 (NMO-IgG: aka)

13

[MS]: What lifestyle advice do you give (1)

Stress reduction (reduced new lesions incidence)

14

[MS]: if you suspect the pt of low levels of sun exposure you give ...

Vit D

15

[MS]: 1st line Tx for an acute relapse is ...

Methylprednisolone (for <3days)

16

[MS]: Up to how many times can you give steroid in 1 year for treatment for an acute relapse

2 (due to SE)

17

[MS]: In relapsing-remitting MS what what 2 mAbs are used

Alemtuzumab
Natalizumab

18

[MS]: ... in CSF (and not in serum) is indicative of some sort of CNS inflammation

Oligoclonal IgG bands

19

[MS]: How does geography affect prevalence of MS

More common the further away from the equator.

20

[MS]: How does temperature affect the disease

Worse at higher temperatures (bath/warm)

21

[MS]: How might visual evoked potentials aid in diagnosis

indicates optic nerve damage

22

[MS]: Tx: Interferons .... and .... reduce relapse and lesion accumulation (no effect on prognosis)

IFN-1alpha
IFN-1beta

23

[MS]: how does optic neuritis present? (2)

decreased central vision
pain on movement

24

[MS]: what 2 things may trigger a worsening of symptoms

heat (e.g. hot bath)
exercise

25

[MS]: what type of MRI scan is used to identify lesion

Gadolinium