Flashcards in Neuromuscular disease Deck (14):
How does botulinum toxin work?
Cleaves proteins involved in vesicle formation and docking
What causes Lambert Eaton myasthenic syndrome?
Antibodies to presynaptic calcium channels
What is Lambert Eaton associated with?
Small cell carcinoma
What is the underlying aetiology of myasthenia gravis?
Impairment of neuromuscular junction transmission usually due to autoantibodies against the nicotinic acetylcholine receptor
75% of MG patients have...
Thymoma or hyperplasia of the thymus
Two peaks of incidence
Females- 3rd decade
Males- 6 or 7th
Clinical features of MG (4)
Muscle fatigability, improves after rest:
proximal muscle weakness
extra-ocular muscle weakness
Bulbar symptoms (3)
Symptomatic treatment of MG (1)
Pyridostigmine (acetylcholinesterase inhibitor)
Potential side effects of pyridostigmine (3)
Potential surgical treatment of MG
Immunomodulating therapy for MG (1)
Management of myasthenic crisis
Intravenous immunoglobulin (works for unknown reason)