Neuromuscular disease Flashcards Preview

Neurology > Neuromuscular disease > Flashcards

Flashcards in Neuromuscular disease Deck (14):
1

How does botulinum toxin work?

Cleaves proteins involved in vesicle formation and docking

2

What causes Lambert Eaton myasthenic syndrome?

Antibodies to presynaptic calcium channels

3

What is Lambert Eaton associated with?

Small cell carcinoma

4

What is the underlying aetiology of myasthenia gravis?

Impairment of neuromuscular junction transmission usually due to autoantibodies against the nicotinic acetylcholine receptor

5

75% of MG patients have...

Thymoma or hyperplasia of the thymus

6

Two peaks of incidence

Females- 3rd decade
Males- 6 or 7th

7

Clinical features of MG (4)

Muscle fatigability, improves after rest:
proximal muscle weakness
extra-ocular muscle weakness
ptosis

8

Bulbar symptoms (3)

"Myasthenic snarl"
Hypernasal speech
Dysphagia

9

Symptomatic treatment of MG (1)

Pyridostigmine (acetylcholinesterase inhibitor)

10

Potential side effects of pyridostigmine (3)

Increased salivation
Bradycardia
Diarrhoea

11

Potential surgical treatment of MG

Thymectomy

12

Immunomodulating therapy for MG (1)

Prednisolone

13

Management of myasthenic crisis

Plasmapharesis
Intravenous immunoglobulin (works for unknown reason)

14

Features of LEMS

Autonomic dysfunction
Hyporeflexia
Weakness