Parkinson's treatment Flashcards Preview

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Flashcards in Parkinson's treatment Deck (11):
1

When should drug treatment for PD commence?

When symptoms become disabling

2

Examples of dopamine receptor agonists (3)

Bromocriptine
Cabergoline
Ropinorole

3

Side-effects/risks of dopamine receptor agonists (3)

Impulse control disorders
Excessive daytime somnolence
Cardiac/pulmonary/retroperitoneal fibrosis

4

What two classes of drug is levodopa often combined with, give an example and state their mechanism of action?

Decarboxylase inhibitor e.g. carbidopa, to reduce peripheral metabolism of dopamine.
COMT inhibitor e.g. entacapone- inhibit dopamine breakdown, help counter the end of dose effect

5

What is the on-off effect sometimes seen with levodopa?

Sudden, sometimes unpredictable changes in symptoms from well-controlled to badly controlled

6

Unwanted effects of levodopa (5)

Reduced effectiveness with time
Dyskinesia
On-off effect
Dry mouth
Palpitations

7

Selegiline is an example of...

Monoamine oxidase B inhibitor

8

What does selegiline do?

Inhibits breakdown of dopamine secreted by dopaminergic neurones

9

How is amantadine thought to work?

Increases dopamine release and inhibits synaptic re-uptake

10

What is the preferred anti-emetic for patients with PD, and why?

Domperidone. Other anti-emetics are dopamine antagonists which cross the blood brain barrier, domperidone does not

11

Madopar (levodopa) may cause what side effect?

Orthostatic hypotension