Neuropathies Flashcards Preview

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Flashcards in Neuropathies Deck (21):
1

Which types of nerve fibres are the largest? (2)

Motor fibres, and sensory fibres for touch, vibration, position and proprioception

2

What happens when large motor fibres (LMN) are damaged?

Symptoms of weakness, muscle wasting, reduced power and absent reflexes

3

Symptoms of autonomic dysfunction (and which type affected) (5)

Postural hypotension (S)
Erectile dysfunction (P)
Nausea and vomiting due to gastroparesis (P)
Horner's (S)
Holmes-Adie pupil (P)

4

In what situation would the sensation of pin prick and temperature be reduced?

When small sensory fibres are damaged

5

What is a "neuropathic" gait?

High stepping gait

6

Describe the pattern of length dependent neuropathy

"Glove and stocking"- "rolls up" the legs and arms as the severity increases

7

Most commmon cause of a glove and stocking distribution of sensory loss/weakness

Diabetic neuropathy

8

Damage to one of more peripheral nerves, usually in association with a systemic cause (WARDS PLC?)

Mononeuritis multiplex

9

Two common causes of mononeuritis multiplex

Diabetes mellitus
Rheumatoid arthritis

10

Differential diagnosis of carpal tunnel syndrome

C8 radiculopathy

11

Acute inflammatory demyelinating polyneuropathy, often following an infection

Guillain-Barre syndrome

12

What are the symptoms of Guillain-Barre syndrome? (1)

Progressive ascending paraplegia

13

Management of Guillain-Barre syndrome (2)

IV immunoglobulin and plasma exchange
25% require mechanical ventilation

14

Causes of death in Guillain-Barre syndrome (2)

Cardiac arrhythmias due to autonomic failure
Type 2 respiratory failure

15

Two chronic demyelinating neuropathies

Chronic inflammatory demyelinating polyradiculopathy
Charcot-Marie-Tooth disease

16

How does Charcot-Marie-Tooth present?

In puberty with weak legs and foot drop with variable sensory/reflex loss; also causes atrophy of hands and legs

17

Inheritance of CMT disease

Most common mutation is inherited autosomal dominantly

18

Treatment of vasculitic axonal neuropathies

Prednisolone + cyclophosphamide

19

Treatment of demyelinating inflammatory neuropathies

IV immunoglobulin, steroids, DMARDs

20

Mostly motor polyneuropathies (3)

CMT
Lead poisoning
Guillaine Barre

21

Mostly sensory polyneuropathies (3)

Diabetic
Renal failure
Leprosy