Neuropathology 2 Flashcards Preview

MD4001 Pathology > Neuropathology 2 > Flashcards

Flashcards in Neuropathology 2 Deck (11):
1

what are some problems with neuropathology research

sampling error
accessibility of tissue
tissue only available late in the disease process

2

what are dawsons fingers

radiographic feature of demyelinating plaques through the corpus callosum,

sign for multiple sclerosis (MS)

3

what is the link to MS and vitamin D

vit D deficiency predisposes individuals

increasing vit D decreases rate of relapse in relapsing remitting MS

vit D is an immunomodulator

4

what virus is MS linked to

EBV

5

does smoking increase the risk of MS

yes

6

what two microscopic features can be seen in Alzeimers

neurofibrillary tangles
amyloid plaques

7

what can cause peripheral neuropathy

diabetes melitus
idiopathic
toxicity
B12 deficiency
post infectious (guillian barre)
paraneoplastic
leprosy
amyloid
charcot marie tooth

8

name some muscle diseases

dystrophies
congenital myopathies
mitochondrial myopathies
metabolic
myotonic (a type of muscular dystrophy)

inflammatory (polymyositis, dermato)
toxic e.g. alchohol
metabolic e.g. cushings
disuse atrophy
rhadomyolysis

9

what muscles are normally sampled in a muscle biopsy

deltoid, quadriceps or tibialis anterior

would also do creatinine phosphokinase and electromyography

10

what are slow twitch fibres innervated by

alpha 2 motor nuerones

11

what are fast twitch fibres innervated by

alpha 1 motor neurone
higher excitation threshold and faster conduction velocity