Nicotinic and Muscarinic Receptors Flashcards Preview

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Flashcards in Nicotinic and Muscarinic Receptors Deck (10)
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1

Muscarninc M1: Location (2)Responses (for each location)

CNS Autonomic ganglia Late EPSP (excitatory postsynaptic potential) ; complex at least arousal, attention analgesia

2

Muscarninc M1: MechanismPrototype agonist/antagonist

Gq/11 --> PLC --> IP3 + DAG --> Ca + PKC (all increase in concentration) Oxotremorine / Pirenzepine

3

Muscarininc M2: Location (4) Responses

All heart SA node : slowed spontaneus depolarization, hyperpolarzationAV node : decrease conduction velocity Atrium : decreased refactory period : decreased contractile forceVentricle : slight decrease in contractility

4

Muscarninc M2: Mechanism Prototype agonist/antagonist

betagamma subunit of G Protein --> inhibits Adenylyl cyclase and increases potassium channel openingnone/ AF-DX117

5

Muscarinic M3: Location (1) ResponseMechanismAntagonist

smooth muscle contraction same as M1hexahydrosiladifenidol

6

Muscarninc M4/5LocationMechanism (2) Antagonist for M4

CNSM4--> M2 and M5 --> M1Himbacine antagonizes M4

7

Nicotinic Nm: Locations Response

Skeletal muscle at NMJEnd -plate depolarization; skeletal muscle contraction

8

Nicotinic Nm: MechanimAgonist/ antagonist

opening of Na/K channels Phenyltrimethylammonium / Tubocurare

9

Nicotininc Nn : Location (3) Responses ( for each loc. )

Autonomic Gnglia : deplarization and firing of postganglionic neuronadrenal medulla : release of catecholaminesCNS : complex, arousal , attention, analgesia

10

Nicotinic Nn:MechanismAgonist/Antagonist

opening of Na/K channel Dimethylphenylpiperazinium / Trimethaphan