Flashcards in Pharm 10 - Adrenergics Deck (41)
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1
rate limiting enyzme for catecholamine synthesis and the sole inhibitor of it
tyrosine hydroxylase; alpha- methyltyrosine
2
MOA of the inhibitors of catecholamine storage (ICS)
short term increase in catecholamine but long term depletion of available pool of catecholamines
3
Inhibitor of Catecholamine Storage used for hypertension (3)
Reserpine, guanethidine, guanadrel
4
Inhibitor of Catecholamine Storage used for ADHD and narcolepsy
amphetamine (narcoleptics) , methylphenidate
5
Inhibitor of Catecholamine Storage used for allergic rhinitis and Nasal Congestion
Pseudoephedrine
6
ADR : GI hemorrhage, thrombocytopenia, dream anxiety disorder impotence and psychotic depression
Reserpine
7
ADR: kidney disease , apnea , orthostatic hypotention fluid retention, dizzines , blurred vision, impotence
Guanethidine , guanadrel
8
ADR: hypertension, tachyarrhythmia, Gilles de la Tourettes syndrome, seizure psychotic disorder w/ prolonged use
Amphetamine, Methylphenidate
9
ADR: A-fib, Ventricular Premature Beats, MI, insomnia, tachyarrhythmia, hypertension
Pseudoephedrine
10
Irreversibly inhibits VMAT but rarely used because of its association with psychotic depression
Reserpine
11
Displaces norepinephrine from the storage vesicles. and can lead to reduced Cardiac Output
Guanethidine, Guanadrel
12
Displace endogenous catecholamines and also weakyl inhibit MAO and block reuptake at NET and DAT, dependence is possible
Amphetamine, Methylphenidate
13
Inhibitors of Catecholamine Reuptake and at what receptor
Cocaine, Imipramine, and Amitriptyline@NET
14
INhibitors of MAO
PICTureS of BoMBs
- Phenelzine
- Iproniazid
- clorgyline
- Tranylcypromine
- Selegine
- Befloxatone
- Moclobemide
- Brofaromine
15
Alpha1-adrenergic agonists (4) and Mechanism
- Phenylephrine, Oxymetazoline, Tetrahydrazoline, Methoxamine (MethPhenOxyTet)
- Activates central Alpha1-adrenergic auto receptors to Increase peripheral resistance
16
Indicated for Opthalmic hyperemia and Nasal Congestion
Phenylephrine (can use in hypotension), Oxymetazoline, Tetrahydrazoline
17
ADR bradycardia, ventricular ectopic beat
methoxamine
18
ADR: cardiac arrythmia + hypertension. rebound nasal condition
Phenylephrine, Oxymetazoline, Tetrahydrazoline
19
Alpha-2 adrenergic antagonists (5) and their MOA
- Clonidine, Dexmedetomidine, Guanabenz, Guanfacine, Methyldopa
- Activate central alpha2-adrenergic auto receptors to inhibit sympathetic outflow from CNS
20
sedation of surgical and ICU pts
dexmedetomidine
21
used for Opioid withdrawl or cancer pain
Clonidine
22
ADR: hepatotoxicity, autoimmune hemolytic anemia
methyldopa
23
ADR : bradycardia and heart failure (4)
Clonidine, Dexmedetomidine, Guanabenz, Guanafacine
24
Used for Hypertenion assoc. with opioid withdrawl
Clonidine
25
DRUG OF CHOICE for hypertension during pregnancy
Methyldopa
26
Beta-adrenergic agonists
- Metaproterenol, Isoproterenol, Salmeterol, Terbutaline, Albuterol, Dobutamine
- (Mista D)
27
Alpha-adrenergic antagonists MOA
block alpha 1 and 2 causing vasodilation, decreased BP and decreased peripheral resistance.
28
Use for Pheochromocytoma-associated hypertension and sweating and Pre-Operative Management of Pheochromocytoma
- Phenoxybenzamine and Phentolamine
29
Use for Benign Prostatic Hyperplasia
- Osins!
- Prazosin, Terazosin, Doxazosin, and Tamsulosin
30
