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Flashcards in Pharm 10 - Adrenergics Deck (41)
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1

rate limiting enyzme for catecholamine synthesis and the sole inhibitor of it

tyrosine hydroxylase; alpha- methyltyrosine

2

MOA of the inhibitors of catecholamine storage (ICS)

short term increase in catecholamine but long term depletion of available pool of catecholamines

3

Inhibitor of Catecholamine Storage used for hypertension (3)

Reserpine, guanethidine, guanadrel

4

Inhibitor of Catecholamine Storage used for ADHD and narcolepsy

amphetamine (narcoleptics) , methylphenidate

5

Inhibitor of Catecholamine Storage used for allergic rhinitis and Nasal Congestion

Pseudoephedrine

6

ADR : GI hemorrhage, thrombocytopenia, dream anxiety disorder impotence and psychotic depression

Reserpine

7

ADR: kidney disease , apnea , orthostatic hypotention fluid retention, dizzines , blurred vision, impotence

Guanethidine , guanadrel

8

ADR: hypertension, tachyarrhythmia, Gilles de la Tourettes syndrome, seizure psychotic disorder w/ prolonged use

Amphetamine, Methylphenidate

9

ADR: A-fib, Ventricular Premature Beats, MI, insomnia, tachyarrhythmia, hypertension

Pseudoephedrine

10

Irreversibly inhibits VMAT but rarely used because of its association with psychotic depression

Reserpine

11

Displaces norepinephrine from the storage vesicles. and can lead to reduced Cardiac Output

Guanethidine, Guanadrel

12

Displace endogenous catecholamines and also weakyl inhibit MAO and block reuptake at NET and DAT, dependence is possible

Amphetamine, Methylphenidate

13

Inhibitors of Catecholamine Reuptake and at what receptor

Cocaine, Imipramine, and Amitriptyline@NET

14

INhibitors of MAO

PICTureS of BoMBs
- Phenelzine
- Iproniazid
- clorgyline
- Tranylcypromine
- Selegine
- Befloxatone
- Moclobemide
- Brofaromine

15

Alpha1-adrenergic agonists (4) and Mechanism

- Phenylephrine, Oxymetazoline, Tetrahydrazoline, Methoxamine (MethPhenOxyTet)
- Activates central Alpha1-adrenergic auto receptors to Increase peripheral resistance

16

Indicated for Opthalmic hyperemia and Nasal Congestion

Phenylephrine (can use in hypotension), Oxymetazoline, Tetrahydrazoline

17

ADR bradycardia, ventricular ectopic beat

methoxamine

18

ADR: cardiac arrythmia + hypertension. rebound nasal condition

Phenylephrine, Oxymetazoline, Tetrahydrazoline

19

Alpha-2 adrenergic antagonists (5) and their MOA

- Clonidine, Dexmedetomidine, Guanabenz, Guanfacine, Methyldopa
- Activate central alpha2-adrenergic auto receptors to inhibit sympathetic outflow from CNS

20

sedation of surgical and ICU pts

dexmedetomidine

21

used for Opioid withdrawl or cancer pain

Clonidine

22

ADR: hepatotoxicity, autoimmune hemolytic anemia

methyldopa

23

ADR : bradycardia and heart failure (4)

Clonidine, Dexmedetomidine, Guanabenz, Guanafacine

24

Used for Hypertenion assoc. with opioid withdrawl

Clonidine

25

DRUG OF CHOICE for hypertension during pregnancy

Methyldopa

26

Beta-adrenergic agonists

- Metaproterenol, Isoproterenol, Salmeterol, Terbutaline, Albuterol, Dobutamine
- (Mista D)

27

Alpha-adrenergic antagonists MOA

block alpha 1 and 2 causing vasodilation, decreased BP and decreased peripheral resistance.

28

Use for Pheochromocytoma-associated hypertension and sweating and Pre-Operative Management of Pheochromocytoma

- Phenoxybenzamine and Phentolamine

29

Use for Benign Prostatic Hyperplasia

- Osins!
- Prazosin, Terazosin, Doxazosin, and Tamsulosin

30

First Dose of these is generally prescribed in small quantities at bedtime due to potential severe postural hypotension

- Zosins!
- Prazosin, Terazosin, Doxazosin