Pharm 10 - Adrenergics

Question 1

rate limiting enyzme for catecholamine synthesis and the sole inhibitor of it

Answer 1

tyrosine hydroxylase; alpha- methyltyrosine

Question 2

MOA of the inhibitors of catecholamine storage (ICS)

Answer 2

short term increase in catecholamine but long term depletion of available pool of catecholamines

Question 3

Inhibitor of Catecholamine Storage used for hypertension (3)

Answer 3

Reserpine, guanethidine, guanadrel

Question 4

Inhibitor of Catecholamine Storage used for ADHD and narcolepsy

Answer 4

amphetamine (narcoleptics) , methylphenidate

Question 5

Inhibitor of Catecholamine Storage used for allergic rhinitis and Nasal Congestion

Answer 5

Pseudoephedrine

Question 6

ADR : GI hemorrhage, thrombocytopenia, dream anxiety disorder impotence and psychotic depression

Answer 6

Reserpine

Question 7

ADR: kidney disease , apnea , orthostatic hypotention fluid retention, dizzines , blurred vision, impotence

Answer 7

Guanethidine , guanadrel

Question 8

ADR: hypertension, tachyarrhythmia, Gilles de la Tourettes syndrome, seizure psychotic disorder w/ prolonged use

Answer 8

Amphetamine, Methylphenidate

Question 9

ADR: A-fib, Ventricular Premature Beats, MI, insomnia, tachyarrhythmia, hypertension

Answer 9

Pseudoephedrine

Question 10

Irreversibly inhibits VMAT but rarely used because of its association with psychotic depression

Answer 10

Reserpine

Question 11

Displaces norepinephrine from the storage vesicles. and can lead to reduced Cardiac Output

Answer 11

Guanethidine, Guanadrel

Question 12

Displace endogenous catecholamines and also weakyl inhibit MAO and block reuptake at NET and DAT, dependence is possible

Answer 12

Amphetamine, Methylphenidate

Question 13

Inhibitors of Catecholamine Reuptake and at what receptor

Answer 13

Cocaine, Imipramine, and Amitriptyline@NET

Question 14

INhibitors of MAO

Answer 14

PICTureS of BoMBs

• Phenelzine
• Iproniazid
• clorgyline
• Tranylcypromine
• Selegine
• Befloxatone
• Moclobemide
• Brofaromine

Question 15

Alpha1-adrenergic agonists (4) and Mechanism

Answer 15

• Phenylephrine, Oxymetazoline, Tetrahydrazoline, Methoxamine (MethPhenOxyTet)
• Activates central Alpha1-adrenergic auto receptors to Increase peripheral resistance

Question 16

Indicated for Opthalmic hyperemia and Nasal Congestion

Answer 16

Phenylephrine (can use in hypotension), Oxymetazoline, Tetrahydrazoline

Question 17

ADR bradycardia, ventricular ectopic beat

Answer 17

methoxamine

Question 18

ADR: cardiac arrythmia + hypertension. rebound nasal condition

Answer 18

Phenylephrine, Oxymetazoline, Tetrahydrazoline

Question 19

Alpha-2 adrenergic antagonists (5) and their MOA

Answer 19

• Clonidine, Dexmedetomidine, Guanabenz, Guanfacine, Methyldopa
• Activate central alpha2-adrenergic auto receptors to inhibit sympathetic outflow from CNS

Question 20

sedation of surgical and ICU pts

Answer 20

dexmedetomidine

Question 21

used for Opioid withdrawl or cancer pain

Answer 21

Clonidine

Question 22

ADR: hepatotoxicity, autoimmune hemolytic anemia

Answer 22

methyldopa

Question 23

ADR : bradycardia and heart failure (4)

Answer 23

Clonidine, Dexmedetomidine, Guanabenz, Guanafacine

Question 24

Used for Hypertenion assoc. with opioid withdrawl

Answer 24

Clonidine

Question 25

DRUG OF CHOICE for hypertension during pregnancy

Answer 25

Methyldopa

Question 26

Beta-adrenergic agonists

Answer 26

- Metaproterenol, Isoproterenol, Salmeterol, Terbutaline, Albuterol, Dobutamine - (Mista D)

Question 27

Alpha-adrenergic antagonists MOA

Answer 27

block alpha 1 and 2 causing vasodilation, decreased BP and decreased peripheral resistance.

Question 28

Use for Pheochromocytoma-associated hypertension and sweating and Pre-Operative Management of Pheochromocytoma

Answer 28

- Phenoxybenzamine and Phentolamine

Question 29

Use for Benign Prostatic Hyperplasia

Answer 29

- Osins! | - Prazosin, Terazosin, Doxazosin, and Tamsulosin

Question 30

First Dose of these is generally prescribed in small quantities at bedtime due to potential severe postural hypotension

Answer 30

- Zosins! | - Prazosin, Terazosin, Doxazosin

Question 31

Use for Organic and Psychogenic Impotence

Answer 31

- Yohimbine

Question 32

Adverse Effects Include Bronchospasm, nervousness, tremor, increased blood pressure, and increased insulin release.

Answer 32

- Yohimbine

Question 33

Alpha1-receptor Antagonist that has more specificity toward smooth muscle in genitourinary tract

Answer 33

- Tamsulosin

Question 34

Beta-Adrenergic Antagonists and Major Use

Answer 34

- "Olol" Drugs | - Hypertension and Angina

Question 35

Beta Antagonist Used for Glaucoma

Answer 35

- Timolol

Question 36

Beta and Alpha1 Antagonists

Answer 36

- Labetalol and Carvedilol

Question 37

Partial Agonists Among Beta Antagonists

Answer 37

- Pindolol and Acebutolol

Question 38

Partial Agonist at Beta 1 and 2 receptors preferred in hypertensive patients who have bradycardia or decreased cardiac reserve

Answer 38

- Pindolol

Question 39

Used for Emergency Beta Blockade, as in Thyroid Storm because of short half life

Answer 39

- Esmolol

Question 40

Extremely lipophilic; CNS concentration is high enough that sedation and decreased libido may result

Answer 40

- Propanolol

Question 41

Beta1 Selective Antagonists

Answer 41

- Esmolol, Metoprolol, Atenolol