Pharm 21 - Vascular Tone Flashcards Preview

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Flashcards in Pharm 21 - Vascular Tone Deck (42)
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1

MOA:Donates NO-->activates guanylyl cyclase and increases dephosphorylation of myosin light chain in vascular smooth muscle= vasodilation

Nitrates, Inhaled NO, Sodium Nitroprusside

2

Tx: short acting (sublingual), long acting (oral) angina

Isosorbide dinitrate

3

Consideration: venous dilation greater than arteriolar

isosorbide dinitrate

4

Organic Nitrates (5)

isosorbide dinitrate, isosorbide 5-mononitrate, nitroglycerin, sodium nitroprusside, inhaled NO gas

5

Tx: prophylaxis angina, chronic IHD

isosorbide 5-mononitrate

6

consideration: 100% bioavailable orally

Isosorbide 5-mononitrate

7

Tx: Agnina attacks, chronic IHD, acute heart failure

Nitroglycerin (NTG)

8

Consideration: Ergotamine may oppose coronary vasodilation of nitrates

NTG

9

Tx: HTN emergency, severe cardiac failure, Ergot alkaloid toxicity

Sodium nitroprusside

10

Consideration: cyanide toxicity (thiocyanate toxicity)

sodium nitroprusside

11

Tx:Neonatal respiratory failure

inhaled NO gas

12

Consideration:selectively dilates pulmonary vasculature

inhaled NO gas

13

Phosphodiesterase Type V (PDE5) Inhibitors (3)

Sildenafil, Vardenafil, Tadalafil

14

MOA:Inhibit PDE5 (enzyme for converting cGMP to GMP) cGMP normally relaxes vessels= dilation (PDE5 inactivate cGMP-->GMP)

Phosphodiesterase Type 5 (PDE5) Inhibitors

15

Tx:Erectile dysfunction

PDE5 inhibitors

16

consideration:concomitant use of organic nitrate vasodilators= Hypotension

PDE5 inhibitors

17

Calcium channel blockers (CCB)

Dihydropyridines: Nidfedipine, amlodipine, felodipine, clevidipine; Benzothiazepine: Diltiazem; Phenylalkylamine: Verapamil

18

MOA:Block influx of calcium (L-type channels)= no actin myosin cross bridge formation= no contraction= dilation

Calcium channel blockers

19

Tx:Angina, HTN, Raynaud's phenomenon, Pre-eclampsia

Dihydropyridines (CCB)

20

Considerations:Amlodipine has higher bioavailability, longer peak time, slower metabolism

Dihydropyridines (CCB)

21

Tx Same as Phenylalkylamine):Prinzmetal angina, HTN, A-fib, Paroxysmal SVT

Benzothiazepine

22

Benzothiazepine medication name

Diltiazem

23

Dihydropyridine medications name (4)

Nidfedipine, Amlodipine, Felodipine, Clevidipine

24

Tx (same as Dihydropyridines):Prinzmetal angina, HTN, A-fib, Paroxysmal SVT

Phenylalkylamine

25

Consideration:concomitent alcohol use will increase alcohol concentration

Phenylalkylamine

26

Phenylalkylamine medication name

Verapamil

27

MOA:Open ATP modulated K+ channels to hyperpolarize membrane= decreased influx of calcium= dilation

K+ channel openers

28

K+ channel opener medications (4)

minoxidil, pinacidil, nicorandil, cromakalim

29

Tx:Severe/refractory HTN; male alopecia (topical minoxidil)

K+ channel openers

30

Considerations:typically used with B-blockers and diuretic

K+ channel openers