Flashcards in Pharm 9 - Cholinergics Deck (31)
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1
Degrades synaptobrevin and thus prevents synaptic vesicle fusion with the axon terminal membrane
- Botulinum Toxin
- Produced by C. Botulinum
2
Inhibit acetylcholinesterase (AChE) by binding to the enzyme's active site. (5)
- Edrophonium
- Neostigmine
- Pyridostigmine
- Ambenonium
- Physostigmine
3
Use for Focal Dystonias, Torticollis, Achalasia, Strabismus, Blepharospasm, Pain Syndromes, Wrinkles, and Hyperhidrosis
- Botulinum Toxin (BoTox)
4
Use for Myasthenia Gravis, Eaton-Lambert Syndrome or other muscles weakness disorders (4)
- Edrophonium
- Neostigmine
- Pyridostigmine
- Ambenonium
5
Use for Reversal of anticholinergic toxicity or induced surgical paralysis
- Physostigmine
6
Has direct cholinergic agonist effect at Nm receptors
- Neostigmine
7
Topical application of (blank, blank) to the cornea of the eye decreases intraocular pressure by facilitating the outflow of aqueous humor
- Cholinesterase Inhibitors
8
AChE Inhibitor encountered as a toxin, used as an insecticide
- Diisopropyl Fluorophosphate
9
AChE Inhibitor Used for Alzheimer's Disease and Dementia
- Tacrine, Donepezil, and Rivastigmine
10
Stimulate Muscarinic Receptor Activity (Muscarinic Receptor Agonists)
- Methacholine
- Carbachol
- Bethanechol
- Cevimeline
- Pilocarpine
11
Used to Diagnose Asthma
Methacholine
12
Muscarinic Receptor Agonist Used for Glaucoma
- Carbachol
13
Muscarinic Receptor Agonist Used for Urinary Tract Motility
- Bethanechol
14
Muscarinic Receptor Agonists Used for Xerostomia in Sjogren's Syndrome
- Cevimeline and Pilocarpine
15
Adverse Effects Include Dyspnea, Lightheadedness, pruritus and throat irritation
- Methacholine
16
Stimulate opening of nicotinic ACh receptor channel and produce depolarization of the cell membrane (creates a depolarizing blockade)
- Succinylcholine
17
Used to induce neuromuscular blockade in surgery and for intubation
- Succinylcholine
18
Adverse Effects Include Muscle Rigidity, myalgia, and raised intraocular pressure
- Succinylcholine
19
Muscarinic Receptor Antagonist used for Anticholinesterase Overdose, Bradycardia, Premedication for anesthetic, and Antidote to Mushroom Poisoning
- Atropine
20
Side Effects Include Raised Intraocular pressure, tachycardia, constipation, xerostomia, and blurred vision
- Atropine
21
Muscarinic Receptor Antagonist used for Motion Sickness, Nausea, and Vomiting delivered via transdermal patch
- Scopolamine
22
Muscarinic Receptor Antagonist Used for Peptic Ulcer Disease (PUD) and induced bradycardia
- Pirenzepine, Methscopolamine, and Glycopyrrolate
23
Muscarinic Receptor Antagonist Used for Asthma and COPD
- Ipratropium and Tiotropium
24
Muscarinic Receptor Antagonist Used for Overactive Bladder and Urge Incontinence
- Oxybutynin, Propantheline, and Terodiline
25
Nicotinic Receptor Antagonists, prevent endogenous ACh binding and subsequent muscle cell depolarization (nondepolarizing blockade)
- Pancuronium, Tubucurarine, Vecuronium
-Trimethaphan and Mecamylamine
26
MOA of Edrophonium, Neostigmine, Pyridostigmine, Ambenonium and Physostigmine
Acetylcholinesterase Inhibitors
27
MOA of Pancuronium, Tubucurarine, Vecuronium, Trimethaphan and Mecamylamine
Nicotinic Receptor Antagonists
28
MOA of Oxybutynin, Propantheline, and Terodiline
Muscarinic Receptor Antagonists
29
MOA of Ipratropium and Tiotropium
Muscarinic Receptor Antagonists
30
