Pharm 9 - Cholinergics Flashcards Preview

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Flashcards in Pharm 9 - Cholinergics Deck (31)
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1

Degrades synaptobrevin and thus prevents synaptic vesicle fusion with the axon terminal membrane

- Botulinum Toxin
- Produced by C. Botulinum

2

Inhibit acetylcholinesterase (AChE) by binding to the enzyme's active site. (5)

- Edrophonium
- Neostigmine
- Pyridostigmine
- Ambenonium
- Physostigmine

3

Use for Focal Dystonias, Torticollis, Achalasia, Strabismus, Blepharospasm, Pain Syndromes, Wrinkles, and Hyperhidrosis

- Botulinum Toxin (BoTox)

4

Use for Myasthenia Gravis, Eaton-Lambert Syndrome or other muscles weakness disorders (4)

- Edrophonium
- Neostigmine
- Pyridostigmine
- Ambenonium

5

Use for Reversal of anticholinergic toxicity or induced surgical paralysis

- Physostigmine

6

Has direct cholinergic agonist effect at Nm receptors

- Neostigmine

7

Topical application of (blank, blank) to the cornea of the eye decreases intraocular pressure by facilitating the outflow of aqueous humor

- Cholinesterase Inhibitors

8

AChE Inhibitor encountered as a toxin, used as an insecticide

- Diisopropyl Fluorophosphate

9

AChE Inhibitor Used for Alzheimer's Disease and Dementia

- Tacrine, Donepezil, and Rivastigmine

10

Stimulate Muscarinic Receptor Activity (Muscarinic Receptor Agonists)

- Methacholine
- Carbachol
- Bethanechol
- Cevimeline
- Pilocarpine

11

Used to Diagnose Asthma

Methacholine

12

Muscarinic Receptor Agonist Used for Glaucoma

- Carbachol

13

Muscarinic Receptor Agonist Used for Urinary Tract Motility

- Bethanechol

14

Muscarinic Receptor Agonists Used for Xerostomia in Sjogren's Syndrome

- Cevimeline and Pilocarpine

15

Adverse Effects Include Dyspnea, Lightheadedness, pruritus and throat irritation

- Methacholine

16

Stimulate opening of nicotinic ACh receptor channel and produce depolarization of the cell membrane (creates a depolarizing blockade)

- Succinylcholine

17

Used to induce neuromuscular blockade in surgery and for intubation

- Succinylcholine

18

Adverse Effects Include Muscle Rigidity, myalgia, and raised intraocular pressure

- Succinylcholine

19

Muscarinic Receptor Antagonist used for Anticholinesterase Overdose, Bradycardia, Premedication for anesthetic, and Antidote to Mushroom Poisoning

- Atropine

20

Side Effects Include Raised Intraocular pressure, tachycardia, constipation, xerostomia, and blurred vision

- Atropine

21

Muscarinic Receptor Antagonist used for Motion Sickness, Nausea, and Vomiting delivered via transdermal patch

- Scopolamine

22

Muscarinic Receptor Antagonist Used for Peptic Ulcer Disease (PUD) and induced bradycardia

- Pirenzepine, Methscopolamine, and Glycopyrrolate

23

Muscarinic Receptor Antagonist Used for Asthma and COPD

- Ipratropium and Tiotropium

24

Muscarinic Receptor Antagonist Used for Overactive Bladder and Urge Incontinence

- Oxybutynin, Propantheline, and Terodiline

25

Nicotinic Receptor Antagonists, prevent endogenous ACh binding and subsequent muscle cell depolarization (nondepolarizing blockade)

- Pancuronium, Tubucurarine, Vecuronium
-Trimethaphan and Mecamylamine

26

MOA of Edrophonium, Neostigmine, Pyridostigmine, Ambenonium and Physostigmine

Acetylcholinesterase Inhibitors

27

MOA of Pancuronium, Tubucurarine, Vecuronium, Trimethaphan and Mecamylamine

Nicotinic Receptor Antagonists

28

MOA of Oxybutynin, Propantheline, and Terodiline

Muscarinic Receptor Antagonists

29

MOA of Ipratropium and Tiotropium

Muscarinic Receptor Antagonists

30

Pirenzepine, Methscopolamine, and Glycopyrrolate

Muscarinic Receptor Antagonists