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Flashcards in Pharm 30 Treatment Questions Deck (15)
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1

What oral agent used to control type II diabetes has the following characteristic?Lactic acidosis (rare but worrisome)

Biguanide: metformin

2

What oral agent used to control type II diabetes has the following characteristic?Most common side effect is hypoglycemia

Sulfonylureas First generation: generally not used
Second generation: Glyburide, glimepiride and glipizide

3

What oral agent used to control type II diabetes has the following characteristic?Often used in combination with any of the other oral agents

Metforminbut many of these agents can be combined

4

What oral agent used to control type II diabetes has the following characteristic?Also help lower triglycerides and LDL cholesterol levels

Biguanides: Metformin

5

What oral agent used to control type II diabetes has the following characteristic?Not safe in settings of hepatic dysfunction or CHF

-Biguanides: metformin
-Glitazones/thiazolidinediones

6

What oral agent used to control type II diabetes has the following characteristic?Should not be used in patients with elevated serum creatinine

Biguanides: metformin (due to risk of lactic acidosis)

7

What oral agent used to control type II diabetes has the following characteristic?Should not be used in patients with liver cirrhosis, elevated serum creatinine or inflammatory bowel disease.

alpha- glucosidase inhibitors: acarbose and miglitol

8

What oral agent used to control type II diabetes has the following characteristic?Hepatic serum transaminase levels should be carefully monitored when using these agents.

-Biguanides: metformin
-Glitazones/thiazolidinediones

9

What oral agent used to control type II diabetes has the following characteristic?Not associated with weight gain, often used in overweight diabetics

Biguanide: metformin

10

What oral agent used to control type II diabetes has the following characteristic?Metabolized by liver; excellent choice in patients with renal disease

Gliazones/thiazolidinediones

11

What oral agent used to control type II diabetes has the following characteristic?Primarily effects postprandial hyperglycemia

alpha-glucosidase inhibitors: acarbose and miglitol

12

What oral agent used to control type II diabetes has the following characteristic?MOA: closes K channel on Beta cells causes depolarization and Ca influc and insulin release

Sulfonylureas: First gen and second gen (glyburide, glimepiride and glipizide)

13

What oral agent used to control type II diabetes has the following characteristic?MOA: inhibits alpha-glucosidase at intestinal brush border

alpha-glucosidase inhibitors: acarbose and miglitol

14

What oral agent used to control type II diabetes has the following characteristic?MOA: agonist at PPAR-gamma receptors and improves target cell response to insulin

Gliazone/thiazolidinediones: pioglitazone and rosglitazone

15

A 40 yo male comes to the ER for Rx of DKA. His type I diabetes is normally well controlled and doesn't know why he has DKA. What is the DDx for his development of his DKA?

-Infection
-Dehydration
-Med omission or reduction
-Severe medical illness (MI, trauma)
-glucocorticoids
-alcohol or drug abuse