Nitrofurantoin

Question 1

What increases the risk of renal neuropathy?

Answer 1

Nitrofurantoin

Renal neuropathy risk is specifically noted with the use of nitrofurantoin.

Question 2

What is the recommended eGFR threshold for avoiding nitrofurantoin?

Answer 2

Less than 45

Nitrofurantoin should not be used if the estimated glomerular filtration rate (eGFR) is below this threshold.

Question 3

What is the advised duration for using nitrofurantoin when eGFR is between 30 to 44?

Answer 3

Short course only (three to seven days)

Caution is advised when using nitrofurantoin with this level of kidney function.

Question 4

What must be monitored during long-term therapy with nitrofurantoin?

Answer 4

Liver function

Long-term use requires careful monitoring of liver health.

Question 5

What are contraindications for using nitrofurantoin?

Answer 5

• Acute porphyria
• G6PD deficiency
• Infants less than three months

These conditions pose significant risks when using nitrofurantoin.

Question 6

In which conditions should nitrofurantoin be used with caution?

Answer 6

• Anaemia
• Diabetes
• Electrolyte imbalances
• Folate deficiencies

Caution is warranted due to the potential for adverse effects.

Question 7

Should nitrofurantoin be used during pregnancy?

Answer 7

Avoid, especially at term

It can lead to neonatal hemolysis, making it risky during late pregnancy.

Question 8

Nitrofurantoin treatment plan

Answer 8