November 30, 2015 - Topical Therapy Flashcards Preview

COURSE 2 > November 30, 2015 - Topical Therapy > Flashcards

Flashcards in November 30, 2015 - Topical Therapy Deck (14):
1

Topical Therapy

Treatment applied to the skin that is directed at the skin.

Exposure is largely limited to the skin. There is a decreased risk of systemic side effects, but sometimes there is a little bit of systemic absorption.

Consists of... a vehicle and active ingredient(s)

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Types of Vehicles

Cream (semi-solid emulsions)

Ointment (greasy)

Lotion (liquid)

Gel (think hair gel)

3

Creams

White, non-greasy

Semi-solid emulsions and are generally preferred by patients for short-term use

4

Ointments

Greasy, similar to plain petrolatum

Generally, ointments are more potent than creams

5

Lotions

More dilute than creams

Easier to use in hairy areas

6

Gels

Cosmetically the most acceptable

May be drying and irritating to the skin

7

Topical Steroid Potency

Can range from 1800x from the weakest to the strongest

 

Typically... hydrocorisone is the weakest, betamethasone valerate is intermediate, and clobetasol is very strong.

8

Clobetasol

One of the most powerful topical steroids

 

Prescribe to thick areas such as the soles of the feet or the palms of the hands

9

Betamethasone Valerate

A "middle of the road" topical corticosteroid

 

Good for treating the torso, arms and legs

10

Hydrocortisone

A quite weak topical corticosteroid

 

Good for treating the face or body folds

11

Side Effects of Topical Steroids

The greatest side effect of topical steroids is skin atrophy

Of the epidermis, dermis, and even subcutis.

Atrophy leads to bruising, telangiectasia, fragile skin, easily irritated skin, and striae (stretch marks).

12

Tachyphylaxis

Loss of effect with prolonged use.

Topical corticosteroids can suffer from this.

13

Topical Calcineurin Inhibitors

Are non-steroidal anti-inflammatories but do not have any skin atrophy or other steroid effects.

Typical side effects can include burning and stinging.

These can be used alone or in conjunction with topical steroids. If steroids are like a "fire extinguisher", TCIs are like "fire retardant".

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