Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

definition of peripherial sensitisation

A

at the site of inflammation you feel pain much better

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

where in the eicosanoids chain do glucocorticoids have their effect

A

at phospholipase A2 - they diminish the whole process - most potent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

localisation of COX1

A

stomach, kidney, platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

localisation of COX2

A

macrophages, fibroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

COX1 production

A

constitutive - all the time produced

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

COX2 production

A

inductive - at site of inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

COX1 effects in stomach

A

produces prostaglandins mainly PGE to protect stomach wall

  • decr HCl
  • incr mucus secretions
  • incr perfusion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what substances inhibit COX3

A

paracetamol, metamizole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

where is COX3 present

A

in CNS, mainly hypothalamus and thalamus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what effects does inhibiting COX3 have on the body

A

great antipyretic and analgesic effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

old, non selective NSAIDs

A

ketoprofen, aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

more selective COX2 inhibitors

A

meloxicam, carprofen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

name two coxibs that are extremely selective

A

deracoxib, firocoxib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

absorption of NSAIDs

A
  • usually weak acids - non ionised forms have better transport through membranes
  • depends on feed
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

distribution of NSAIDs

A
  • extensive albumin binding - cannot enter milk
  • hypoalbuminaemia
  • interactions
  • loading dose
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

metabolism of NSAIDs

A

mainly glucoronic acid conjugation - feline sensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

while there is no NSAIDs authorised for cats for more than one week, which one is actually safe long term

A

meloxicam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

excretion NSAIDs

A

urine in both inactive and active forms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

where in the body would you find GI ulceration as a side effect

A

stomach and duodenum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

two causes of GI ulceration as a side effect

A
  • local irritation - ion trapping of weak acids

- PGE decr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

can this GI ulceration be avoided by injecting the drugs

A

no, bc the PGE decr can cause it anyway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

how do we treat GI ulceration

A

proton pump inhibitors eg omeprazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

should we give NSAIDs to patients with dehydration

A

no hydrate the animal first - kidney damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

due to the kidney damage, which limitations should we put on usage of NSAIDs

A
  • rehydrate first
  • not during anaesthesia - only post operative
  • not with preexisting renal disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
which dog breed is most prone to idiosyncratic reactions with carprofen
golden retrievers
26
how often is hepatotoxicity observed as a possible side effect
rarely
27
why shouldnt we use paracetamol in cats
leads to methaemoglobinemia - seriously toxic
28
when can the side effect of platelet aggregeation inhibiton be useful
during thrombosis
29
which NSAIDs are more prone to platelet aggregation inhibiton
aspirin, flunixin, tolfenamic acid, ketoprofen
30
why should we be careful when using NSAIDs in arthritis patients
bc they can cause proteoglycan synthesis inhibiton - damages cartilage
31
which NSAIDs are more prone to proteoglycan synthesis inhibition
aspirin, ketoprofen, ibuprofen, naproxen
32
why are NSAIDs not recommended for use during pregnancy, esp the first trimester
they can cause fetal damage, teratogenicity
33
which NSAID in particular is known to have no effect on cartilage
maloxicam
34
why should we be careful when using NSAIDs around the time of parturition
they can cause placenta retention
35
the time period when we should avoid using NSAIDs around parturition
48hrs before to 36hrs after
36
which drug can be used safely around parturition
maloxicam
37
groups of acidic active substances
- salicylates - arilpropionic acids - heteroaryl acetic acids - anthranilic acids - butylpyrazolidines - oxicams
38
groups of non acidic active substances
- anilin derivatives | - pyrazolones
39
coxibs
- deracoxib - firocoxib - robenacoxib - cimicoxib - mavacoxib
40
salicylates
- acetylsalicilic acid - Na salicylate - sulfasalazine, mesalazine
41
arilpropionic acids
- ketoprofen - vedaprofen - carprofen
42
heteroaryl acetic acids
diclofenac
43
anthraanilic acids
- flunixin meglumine | - tolfenamic acid
44
butyl pyrazolidines
phenylbutazone
45
oxicams
- piroxicam | - meloxicam
46
anilin derivatives
paracetamol
47
pyrazolones
metamizole sodium
48
possible side effects from NSAIDs
- GI ulceration - kidney damage - hepatoxcity - platelet aggregation inhibition - methaemoglobinaemia - proteoglycan synthesis inhibition - fetal damage - placenta retention
49
which species can acetylsalycilic acid be used in
dogs, farm animals, not cats
50
in which farm animals is acetylsalycilic acid usually used in
poultry, swine
51
Na salicylate is used in which species
only farm animals, added to water
52
which is safer, acetylsalycilic acid or Na salicylate
Na salicylate - ore COX2 selective
53
in which species are sulfasalazine and mesalazine used
dogs and humans
54
indication for sulfasalazine and mesalazine
chronic colitis
55
what does ketoprofen do to platelet aggregation
significantly inhibits
56
ketoprofen use in cats
short term safety, best antipyretic in cats, v short half life
57
in which form does vedoprofen come for horses
as an oral paste
58
vedaprofen can be used in which species
horses
59
is vedaprofen selective
yes, COX2 selective
60
possible idiosyncratic reaction from carprofen in golden retrievers
hepatopathy - be careful when you give with other hepatotoxic drugs
61
carprofen duration in cattle
4-5 days
62
why is the WP for milk carprofen 0 days
because high albumin binding
63
can carprofen be given lifelong
yes
64
loading carprofen dose ca
po,sc,iv 4.4mg/kg
65
maintainence dose carprofen ca
2.2mg/kg
66
can carprofen be used in exotics
yes
67
side effects carprofen
no cartilage damage, rare side effects - COX2 selective
68
diclofenac is toxic for which species
dogs, cats and birds
69
what does flunixin meglumine do to platelet aggregation
inhibits -causes bleeding
70
why is there a flunixin meglumine pour on solution in cattle
the half life is short - decr absorption lasts longer
71
why is flunixin meglumine useful for mastitis, enteritis and colic
its antiendotoxic
72
why is flunixin meglumine frequently used in Eq
its spasmolytic
73
is tolfenamic acid long term in cats
no, short term
74
what does tolfenamic acid do to platelet aggregation
inhibits
75
in which species is phenylbutazone still used
equine, as an ointment
76
indications for piroxicam
oncology, prostate and urinary bladder tumours - lot of side effects
77
meloxicam loading dose Car
0.2mg/kg SID
78
meloxicam can be given how
inj and PO
79
meloxicam maintainance dose Car
0.1mg/kg SID
80
meloxicam large animals loading dose
0.4mg/kg
81
meloxicam large animals maintainence dose
0.6mg/kg
82
why is meloxicam useful for mastitis, enteritis and colic
its antiendotoxic
83
which COX does paracetamol inhibit
COX3 - analgesic, antipyretic
84
effect of metamizole sodium in cats
CNS signs, excitation, salivation
85
paracetamol dose cats
NEVER GIVE
86
metamizole sodium dose
20-30mg/kg
87
metamizole sodium effect
not specific but mainly COX3
88
species you can use deracoxib in
dog
89
firocoxib can be used in which species
dog, horse
90
firocoxib selectivity
highly selective COX2
91
robenacoxib species
dog/cat
92
robenacoxib how can it be given
inj
93
mavacoxib half life
long, 5-7 days
94
mavacoxib duration of action
3-4weeks
95
bioavaliability of mavacoxib with food
80%
96
bioavaliability of mavacoxib without food
20%
97
mavacoxib percent of albumin binding
98%
98
first repeat of mavacoxib
after 2wks
99
second onwards repeat of mavacoxib
every 4wks

Pharmacology (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions