Overview Of Antibacterial Therapy (word Doc) Flashcards Preview

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Flashcards in Overview Of Antibacterial Therapy (word Doc) Deck (40)
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1

Staph, Strep, and Enterococci are what category of bacteria?

Gram Positive Cocci

2

N gonorrheae, N meningitidis, and M catarrhalis are what category of bacteria?

Gram negative cocci

3

Bacillus anthracis, Listeria monocytogenes are what category of bacteria?

Gram positive rods

4

H influenzae, E coli, and Pseudomonas aeruginosa are what category of bacteria?

Gram negative rods

5

Clostridium difficile, tetani, and botulinum are what category of bacteria?

Anaerobes: Gram Positive rod

6

Bacteroides fragilis is what category of bacteria?

Anaerobe: Gram negative rod

7

Chlamydia, Mycoplasma, and Rickettsia are what category of bacteria?

Atypical

8

Name the 8 bacteria most commonly seen in meningitis. (Hint: BEHLN-SSS)

-Bacteroides
-E coli
-H influenza
-Listeria monocytogenes
-N meningitidis
-Staph aureus
-Strep pneumo
-Strep pyogenes

9

Name the 4 bacteria most commonly associated with skin and soft tissue infections. (Hint: CPSS)

-Clostridia species
-Pseudomonas aeruginosa
-Staph aureus
-Strep pyogenes

10

Name the 3 most common bacteria assoc. w/ Endocarditis. (Hint: SSS)

Staphy aureus
Srep pyogenes
Strep viridans

11

Name the 2 most common bacteria assoc. w/ URI’s. (Hint: SS)

Strep pneumoniae
Strep pyogenes

12

Name the 3 most common bacteria assoc. w/ Lower respiratory tract infections. (Hint: CMS)

Chlamydia pneumoniae
Mycoplasma pneumoniae (walking pneumonia)
Strep pneumo

13

Name the two most common bacteria assoc. w/ hospital acquired lung infections. (Hint: BP)

Bacteroides fragilis
Pseudomonas aeruginosa

14

Name the 3 most common bacteria assoc. w/ PID (pelvic inflammatory disease) (Hint: BCN)

Bacteroides species
Chlamydia trachomatis
N gonorrhea

15

Name the 2 most common bacteria assoc. w/ UTI’s. (Hint: EP)

E Coli
Pseudomonas aeruginosa

16

Name the 3 most common bacteria assoc. w/ intra-abdominal infections. (Hint: CEB)

C difficile
E coli
Bacteroides fragilis

17

Name one bacteria assoc. w/ liver and pancreas infections.

Bacteroides fragilis

18

Name the most common bacteria related to mouth infections.

Strep viridans

19

Name the 4 most common bugs assoc. w/ bone and joint infections. (Hint: NPSS)

N gonorrhoeae
Pseudomonas aeruginosa
Strep pneumo
Staph aureus

20

Name the 2 most common bugs assoc. w/ genital infections. (Hint: CN)

Chlamydia trachomatis
N gonorrhoeae

21

Name the 4 types of abx that have MOA’s for cell wall synthesis. (Hint: VPMC)

-Vancomycin (glycopeptide, gram pos, MRSA)
-Penicillins (Gram pos bugs)
-Monobactams (Aztreonam, Gram Neg, Pseudomonas)
-Cephalosporins (1st gen gram pos Cephalexin/Cefazolin, 2nd gen more gram neg Cefuroxime, 3rd gen less gram pos more gram neg Ceftriaxone/Cefotaxime/Cefpodoxime, 4th gen Cefepime covers Pseudomonas, 5th gen Ceftaroline covers MRSA)

22

Name the 4 types of abx whose MOA works on nucleic acids (ie: DNA gyrase, RNA polymerase, and DNA) (HINT: FRMN)

1)Fluoroquinolones: Gram neg/pos, good respiratory penetration
-Ciprofloxacin (covers Pseudomonas, only one non-respiratory, used for UTI and lower abd infx)
-Levofloxacin (covers pseudo)
-Moxifloxacin (only one that doesn’t cover pseudomonas)
2) Riffffffampin for H infffffffluenzae
3) Metronidazole (anaerobic below diaphragm)
4) Nitrofurantoin (used for UTI’s and ear infections)

23

Name the 4 types of abx whose MOA works on inhibition of protein synthesis. (TAMC)

1) tetracyclines: Gram pos, MRSA coverage
-doxycycline
-tetracycline
-minocycline
2) Aminoglycosides: Gram Neg with anti-Pseudomonal activity; toxicities assoc. w/ them such as ototoxic and nephrotoxic
-Gentamicin
-Tobramycin
-Amikacin
3)Macrolides (azithro, erythro, clarithromycin)
-atypical pneumonia coverage, H influenzae
-azithro (strep pneumo is resistant)
4) Clindamycin
-Gram pos and good anaerobic coverage

24

Name one abx whose MOA is protein synthesis (tRNA).

-Oxazolidinones: Gram Pos, MRSA, VRE
-Linezolid
-Tedizolid

25

Name two abx whose MOA’s work on cell membranes.

1)Lipopeptide: Gram Pos MRSA and VRE; NO LUNG PENETRATION
-Daptomycin
2) Polymyxins: used in abx skin ointments like bacitracin

26

Name the one abx whose MOA works on Folic Acid Metabolism.

-Trimethoprim Sulfamethoxazole (Bactrim): Gram Neg and MRSA

27

Selective toxicity: bacteria must synthesize folate intracellularly while mammalian cells can take up folate from the environment. Which abx class acts on folate metabolism?

Trimethoprim sulfamethoxazole (Bactrim)

28

Selective toxicity: certain abx can work on protein synthesis, specifically ribosomes, because humans have 40s/60s ribosomes whereas bacteria have 30s/50s ribosomes. What 4 abx work on protein synthesis inhibition?

-Aminoglycosides (gentamicin)
-Tetracyclines (doxycycline)
-Lincosamides (clindamycin)
-Macrolides (azithromycin, clarithromycin, etc)

29

Selective toxicity: bacterial nucleic acid synthesis is different from humans. Bacteria use DNA gyrase for their circular DNA, while humans use topoisomerase. Name the 4 abx classes that work on nucleic acid synthesis. (Hint: FRNN)

-Fluoroquinolones (cipro, levo)
-Rifampin
-Nitroimidazole (Metronidazole)
-Nitrofurantoin

30

Selective toxicity: human cells don’t have a cell wall. What 5 abx classes inhibit cell wall synthesis? (Hint: LPMCC)

-Lipopeptide (Vancomycin)
-Penicillins (amoxicillin)
-Cephalosporins (cefepime, ceftaroline)
-Monobactams (Aztreonam)
-Carbapenems (dori, erta, miri)