Flashcards in Protein synthesis inhibitors - clindamycin, aminoglycosides Deck (16)
Is clindamycin bacteriocidal or bacteriostatic?
static, but can be cidal at high concentrations on certain organisms
clindamycin is used for what type of infection
c. skin only
b. clindamycin is used for severe infections (mainly severe anaerobic infections) - no gram neg cocci coverage
What gram pos cocci are effectively treated by clindamycin
Strep. pneumoniae and S. pyogenes -- pneumonia, pharyngitis (alternative if penicillin allergic)
Staphylococcus aureus (MSSA)-- osteomyelitis (alternative if penicillin allergic)
Staphylococcus aureus (MRSA) -- localized cutaneous infection
what anearobes are treated by clindamycin?
Clostridium perfringens (gram + rod)-- gas gangrene, food poisoning
Bacteroides fragilis (gram – rod) -- intraabdominal and brain abscess
Propionobacterium acnes (gram + rod) -- acne (topically)
Clindamycins penetrate most tissues well but especially well into ______ but poorly into _____
A. lungs, GI
B. Skin, GU
C. Bone, CSF
C. Bone, CSF
Clindamycin is metabolized in the______.
Liver. The biliary excretion. iT is also excreted in breast milk
An adverse reaction that causes a c. diff infection
psuedomembrane colitis. (he mentions it is probably no worse than other broad spectrum agents
Name the aminoglycosides
Streptomycin, Tobramycin, Gentamicin, Amikacin, Kanamycin, Neomycin
Are the aminoglycosides bacteriocidal or bacteriostatic
clinically - cidal
but static in high concentrations
are aminoglycosides effective against anaerobes?
Nope, they require O2 to get into the bacteria
Aminoglycosides are not widely used because of?
Gram negative bacilli that aminoglycosides are effective on
Pseudomonas aeruginosa infections in any organ or tissues (especially nosocomial)
E. coli, Klebsiella, Serratia, Proteus, Enterobacter (enteric gram negative) urinary tract infections, lower respiratory infections, bacteremias
Mycobacterium tuberculosis tuberculosis [Streptomycin plus multiple antitubercular drugs]
gram pos cocci that aminoglycosides are effective on
Enterococci bacteremia, endocarditis, intraabdominal infections [Gentamicin plus a penicillin or vancomycin]
Aminoglycosides are poorly absorbed orally. They are rapidly abosorbed via _____
Aminoglycosides accumulate in the______ and the ______ causing ototoxicity and renal toxicity
renal cortex and inner ear