Protein synthesis inhibitors - clindamycin, aminoglycosides Flashcards Preview

RRPA Pharmacology II > Protein synthesis inhibitors - clindamycin, aminoglycosides > Flashcards

Flashcards in Protein synthesis inhibitors - clindamycin, aminoglycosides Deck (16)
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Is clindamycin bacteriocidal or bacteriostatic?

static, but can be cidal at high concentrations on certain organisms


clindamycin is used for what type of infection
a. mild
b. severe
c. skin only

b. clindamycin is used for severe infections (mainly severe anaerobic infections) - no gram neg cocci coverage


What gram pos cocci are effectively treated by clindamycin

Strep. pneumoniae and S. pyogenes -- pneumonia, pharyngitis (alternative if penicillin allergic)
Staphylococcus aureus (MSSA)-- osteomyelitis (alternative if penicillin allergic)
Staphylococcus aureus (MRSA) -- localized cutaneous infection


what anearobes are treated by clindamycin?

Clostridium perfringens (gram + rod)-- gas gangrene, food poisoning
Bacteroides fragilis (gram – rod) -- intraabdominal and brain abscess
Propionobacterium acnes (gram + rod) -- acne (topically)


Clindamycins penetrate most tissues well but especially well into ______ but poorly into _____
A. lungs, GI
B. Skin, GU
C. Bone, CSF

C. Bone, CSF


Clindamycin is metabolized in the______.

Liver. The biliary excretion. iT is also excreted in breast milk


An adverse reaction that causes a c. diff infection

psuedomembrane colitis. (he mentions it is probably no worse than other broad spectrum agents


Name the aminoglycosides

Streptomycin, Tobramycin, Gentamicin, Amikacin, Kanamycin, Neomycin


Are the aminoglycosides bacteriocidal or bacteriostatic

clinically - cidal
but static in high concentrations


are aminoglycosides effective against anaerobes?

Nope, they require O2 to get into the bacteria


Aminoglycosides are not widely used because of?



Gram negative bacilli that aminoglycosides are effective on

Pseudomonas aeruginosa  infections in any organ or tissues (especially nosocomial)
E. coli, Klebsiella, Serratia, Proteus, Enterobacter (enteric gram negative)  urinary tract infections, lower respiratory infections, bacteremias
Mycobacterium tuberculosis  tuberculosis [Streptomycin plus multiple antitubercular drugs]


gram pos cocci that aminoglycosides are effective on

Enterococci  bacteremia, endocarditis, intraabdominal infections [Gentamicin plus a penicillin or vancomycin]


Aminoglycosides are poorly absorbed orally. They are rapidly abosorbed via _____

intramuscular injection.


Aminoglycosides accumulate in the______ and the ______ causing ototoxicity and renal toxicity

renal cortex and inner ear


Because they are not metabolized and they have a haf life of 2-3 hours aminoglycosides can be given how?

in single doses.